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蚂蚁淘在线 / 品牌中心 / Lifespan / Lifespan/PathPlus™ Polyclonal Rabbit anti‑Human EDNRB / Endothelin B Receptor Antibody (N‑Terminus, IHC, WB) LS‑A54/50 µg (1 mg/ml)/LS-A54-50
商品描述
Specifications
Description
Endothelin receptor type B (EDNRB) is expressed in most tissues. Mutations in this receptor are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. EDNRB has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system. A splice variant, termed SVR, has been described; the sequence of the ETB-SVR receptor is identical to ET-B receptor, with the exception of the intracellular C-terminal domain. While both splice variants bind endothelin ET1, they exhibit different responses, which suggests that they may be functionally distinct.References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
(2) Publication(s)
Target
Human EDNRB / Endothelin B Receptor
Synonyms
EDNRB | ABCDS | Endothelin B receptor | Etb receptor | ET-B | Et-b receptor | Et-b-r | ET-RB | ETBR | ETRB | Etb-svr | WS4A | Endothelin receptor type B | ET-BR | ETB | HSCR | HSCR2
See All EDNRB / Endothelin B Receptor Antibodies
Host
Rabbit
Reactivity
Human, Dog(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated.Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 19 amino acid peptide from N-Terminus extracellular domain of human EDNRB. Percent identity with other species by BLAST analysis: Human, Dog (100%); Gorilla, Gibbon (95%); Monkey (89%); Marmoset (84%).
Epitope
N-Terminus
Specificity
Human EDNRB. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PTPN5 (68%).
Applications
- IHC
- IHC - Paraffin (4 - 11 µg/ml)
- ICC
- Western blot
 | Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agentsABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more. |
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio GuaranteeAbout EDNRB / Endothelin B Receptor
P24530NM_000115NP_000106.1
