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Advanced immunochemical/Heat shock protein 27 (HSP27), human/0.1 mg/8-HSP27

价格
¥18000.00
货号:8-HSP27
浏览量:61
品牌:Advanced immunochemical
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商品描述

General Category:

    Antigens » Neuroscience

Disease Category:

    Neuroscience » Antigens
Source:
Recombinant E. coli
Analysis:
Purity > 95 % (SDS-PAGE).Protein concentration is determined by BCA method.
Immunoreactivity:
Immunoreactivity is confirmed by reaction with monoclonal mouse antibodies against HSP25/27.
Purification:
Extraction, ion-exchange chromatography, gel-filtration.
Presentation:
Lyophilized from solution in 20 mM Tris-acetate, pH 7.6, 10 mM NaCl, 0.1 mM EDTA, 0.1 mM PMSF,15 mM β-mercaptoethanol.
Storage Conditions:
-20 °C (between -15 and -30 °C allowed)
Other information:
Avoid repeated freezing and thawing.It is recommended to aliquot the product.
Material safety note:
This product is sold for research use only. Standard Laboratory Practices should be followed when handling this material.
Advanced immunochemical高敏C反应蛋白人C反应蛋白(CRP)是所谓的急性期蛋白之一。它在血液中的浓度随着对炎症的反应而迅速增加。CRP是224个残基蛋白,单体分子量约为25 kDa,pI 6.4(1-4)。它属于五味子毒素,这是一种进化保守的蛋白质家族,其特征在于钙依赖性配体结合和五个单体的对称性,这些单体在中心孔周围形成一个环(5)。CRP在体内的确切功能尚不完全清楚。已证明CRP参与炎症以及先天免疫过程。CRP的重要生物活性取决于其与各种配体(例如受损细胞膜,凋亡细胞和纤连蛋白)的结合能力,对磷胆碱残基的亲和力最高。当CRP与配体结合时,它可以被补体成分C1q识别,从而激活经典补体途径。另一方面,CRP通过与补体因子H相互作用来调节替代补体途径