General Category:

Monoclonal antibodies » Biodefense

Disease Category:

Biodefense » Monoclonal Antibodies

MAbs:

SA26, SA27Hybridoma clones have been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with B. anthracis spore extract.

Specificity:

MAbs SA26 and SA27 recognize 92-94K protein bands in Western blotting of B. Anthracis spore extract. No cross-reactivity found in ELISA with B. anthracis vegetative cells, B. globigii, B. subtilisand B. cereus spores.

MAb Isotypes:

IgG2a for MAbs SA26 and SA27

Applications:

MAb SA26 is suitable for coating and MAb SA27 could be used as a conjugate in sandwich ELISA for anthrax spore determination.Both MAbs are working in Western blotting.

Purification:

Chromatography on protein G Sepharose

Presentation:

PBS, pH 7.4, 0.1 % sodium azide (NaN3)

Storage Conditions:

+ 4 °C

Material Safety Note:

This product is sold as an antibody preparation for research use only. Standard Laboratory Practices should be followed when handling this material.Contains sodium azide (0.1 %) as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

Advanced immunochemical高敏C反应蛋白人C反应蛋白（CRP）是所谓的急性期蛋白之一。它在血液中的浓度随着对炎症的反应而迅速增加。CRP是224个残基蛋白，单体分子量约为25 kDa，pI 6.4（1-4）。它属于五味子毒素，这是一种进化保守的蛋白质家族，其特征在于钙依赖性配体结合和五个单体的对称性，这些单体在中心孔周围形成一个环（5）。CRP在体内的确切功能尚不完全清楚。已证明CRP参与炎症以及先天免疫过程。CRP的重要生物活性取决于其与各种配体（例如受损细胞膜，凋亡细胞和纤连蛋白）的结合能力，对磷胆碱残基的亲和力最高。当CRP与配体结合时，它可以被补体成分C1q识别，从而激活经典补体途径。另一方面，CRP通过与补体因子H相互作用来调节替代补体途径