| 货号： | CD7-H52A5-1mg |
| 供应商： | ACROBiosystems |
| 数量： | In Stock |
| 英文名： | Human CD47 Protein, mouse IgG2a Fc Tag, low endotoxin |
| 规格： | 1mg |
内毒素:Less than 0.1 EU per μg by the LAL method. 纯度:>95% as determined by SDS-PAGE. 活性:Measured by its binding ability in a functional
ELISA against immobilized Human SIRP alpha (HPLC-verified), His Tag (Cat# SIA-H5225, 0.2 μg/mL). The linear range is 0.5-8 ng/mL. 产品背景:Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. 产品描述:This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.8 kDa. The protein migrates as 50-66 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation and 100-130 kDa under non-reducing (NR) condition. 温馨提示：不可用于临床治疗。
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