- SynonymIL7Ra,CD127,TSLP R,CRLF2,IL-XR,ILXR,p2RY8/CRLF2 fusion,TSLP receptor,TSLPR,CRL2,CRLF2Y,Cytokine receptor-like 2
- SourceHuman IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (ILR-H5255) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Asp 239 (IL-7 RA) & Gln 23 - Lys 231 (TSLP R) (Accession # P16871-1 (IL-7RA) &Q9HC73-1).Predicted N-terminus: Glu 21 (IL-7 RA) & Gln 23 (TSLP R)Request for sequence
- Molecular Characterization
Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag is produced by co-expression of IL-7 RA and TSLP R, has a calculated MW of 51.4 kDa (IL-7 RA) and 50.4 kDa (TSLP R). Subunit IL-7 RA is fused with a human IgG1 Fc fragment at the C-terminus and subunit TSLP R is fused with a human IgG1 Fc fragment at the C-terminus.
- Endotoxin
- Formulation
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- Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
- Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than .
- BackgroundTSLP is a pleiotropic cytokine originally characterized as a lymphocyte growth factor. Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma. Human TSLP exerts its biological activities by binding to a high-affinity heteromeric receptor complex composed of TSLPR and IL- 7 receptor and initiates signaling in cells co-expressing TSLPR and IL-7R.
- References
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