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蚂蚁淘在线 / 品牌中心 / ACROBiosystems / ACROBiosystems/Human OMgp / OMG Protein, His Tag/100ug/OMG

ACROBiosystems/Human OMgp / OMG Protein, His Tag/100ug/OMG

价格
￥30000.00
货号：OMG
浏览量：61
品牌：ACROBiosystems
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商品描述
  • Synonym
    OMG,OMGP
  • Source
    Human OMgp, His Tag (OMG-H5228) is expressed from human 293 cells (HEK293). It contains AA Ile 25 - Asn 420 (Accession # AAH18050).
    Predicted N-terminus: Ile 25
    Request for sequence
  • Molecular Characterization
    Online(Ile 25 - Asn 420) AAH18050

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 45.5 kDa. The protein migrates as 90-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >92% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human OMgp, His Tag (Cat. No. OMG-H5228) SDS-PAGE gel

Human OMgp, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.

  • Background
    Oligodendrocyte-myelin glycoprotein (OMG or OMGP), is a cell membrane protein which contains eight LRR (leucine-rich) repeats and one LRRNT domain. OMG / OMGP is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the central nervous system (CNS). OMG / OMGP play roles in both the developing and adult central nervous system. OMG / OMGP may also be involved in the formation and maintenance of myelin sheaths.
  • References
    • (1)Mikol D.D., et al., 1990, J. Cell Biol. 110:471-479.
    • (2)Mikol D.D., et al., 1988, J. Cell Biol. 106:1273-1279.

  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

ACROBiosystems治疗性抗体的功效不仅取决于Fab片段及其与靶抗原的结合活性，还取决于Fc片段及其与关键Fc受体的相互作用。Fc片段对FcRn的结合亲和力（FCGRT＆B2M）将预测抗体的半衰期，而Fc片段与FcγRIIIa（CD16a）之间的结合亲和力将影响抗体引发ADCC的能力（抗体依赖性细胞介导的细胞毒性）。因此，必须在抗体工程化过程中针对一组受体测试候选人。ACROBiosystems提供了完整的重组Fc受体蛋白集合，包括它们的常见变体，以帮助您加快mAb的开发。