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academy biomed/[P01] Human Albumin/1.0 mg/10P-AL101

价格
¥2040.00
货号:10P-AL101
浏览量:127
品牌:academy biomed
服务
全国联保
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商品描述
Concentration:1 mg / ml, determined by the Lowry method
Purification:Repurified from HPLC
Purity:≥ 99% by SDS-PAGE
Buffer:In 75 mM PBS, 75 mM NaCl, 0.02 % NaN3, 0.5 mM EDTA, pH 7.3.
Storage:-20°C for long-term storage, 4°C for short- term storage. Aliquot to avoid repeated freezing and thawing.

 

Importance

Human albumin constitutes around 55% of the protein present in the plasma of normal healthy individuals. It is a single polypeptide chain of 585 amino acids with a molecular weight of 66 kDa.

The functions of human serum albumin include maintaining oncotic pressure; binding substances or drugs; regulating endogenous substances, metabolism; plasma buffer; antioxidant function; maintaining microvascular integrity; anticoagulant effects; inflammatory/anti-inflammatory effects; cell-signaling process. (Nicholson et al., 2000; Evans, 2002) Albumin also has functions that may play a critical role and have a great impact on different types of diseases, including hypo-albumin aemia and peripheral oedema. (Caironi et al. 2009)

Caironi, Pietro, and Luciano Gattinoni. “The clinical use of albumin: the point of view of a specialist in intensive care.” Blood Tranfusion 7.4 (2009): 259-67.

Evans, T. W. "Review Article: Albumin as a Drug-biological Effects of Albumin Unrelated to Oncotic Pressure." Alimentary Pharmacology and Therapeutics 16 (2002): 6-11.

Nicholson, J. P., M. R. Wolmarans, and G. R. Park. "The Role of Albumin in Critical Illness." British Journal of Anaesthesia 85.4 (2000): 599-610. 

 

Citations

 

[P01]2003Weeks, B. L.; Camarero, J.; Noy, A.; Miller, A. E.; Stanker, L.; Yoreo, J. J. de (2003): A microcantilever-based pathogen detector. In Scanning 25 (6), pp. 297–299. DOI: 10.1002/sca.4950250605.
[P01]2001Wu, G.; Datar, R. H.; Hansen, K. M.; Thundat, T.; Cote, R. J.; Majumdar, A. (2001): Bioassay of prostate-specific antigen (PSA) using microcantilevers. In Nature Biotechnology 19 (9), pp. 856–860. DOI: 10.1038/nbt0901-856.
academy biomed[A05]绵羊抗人类载脂蛋白AII多克隆抗体12A-S1a学院生物医学公司$ 155.00$ 155.00目录号数量1寄主物种: 羊浓度: 1毫克/毫升(OD 1.35 / 280 nm)抗原: 人类载脂蛋白AII纯化: 亲和纯化缓冲: 75 mM磷酸钠,75 mM NaCl,0.5 mM EDTA,0.02%NaN3,pH 7.2特异性 与人载脂蛋白AII特异性结合。免疫印迹和ELISA的稀释范围:1,000至80,000。用: 该抗体可用于检测血浆和脂蛋白中的载脂蛋白AII,免疫测定,免疫印迹,酶结合或生物素化。存储: -20°C长期保存,4°C短期保存。等分试样,以避免反复冻结和解冻。 *这些产品仅用于研究或制造用途,不能用于人体治疗或诊断应用。 重要性Apo AII占HDL的25%。它在人血浆中以77条氨基酸残基的2条相同链的二聚体形式存在,并通过二硫键连接。据报道,单链的分子量为8.7kDa(Brewer等,1972)。对小鼠的研究报道,apoAII可能具有促动脉粥样硬化作用(Warden等,1993)。然而,一项大型的欧洲前瞻性研究中的病例对照研究表明,血浆Apo AII浓度与冠心病事件密切相关(Birjmohun等,2007)。Birjmohun,RS,GM Dallinga-Thie,JA Kuivenhoven,ESg Stroes,JD Otvos,NJ Wareham,R.Luben,JJp Kastelein,K.-T. Khaw和SM Boekholdt。“载脂蛋白A-II与未来冠状动脉疾病的风险成反比。” 循环116(2007):2029-035。Brewer,HB,SE Lux,R.Ronan和KM John。“人ApoLp-Gln-II(apoA-II),一种从高密度脂蛋白复合物中分离的载脂蛋白的氨基酸序列。” 美国国家科学院院刊69.5(1972):1304-308。Warden,C.,C.Hedrick,J.Qiao,L.Castellani和A.Lusis。“过表达载脂蛋白A-II的转基因小鼠中的动脉粥样硬化。” 科学261(1993):469-72。