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Caspase-11 (mouse); Protease ICH-3 (mouse)

Monoclonal Antibody

8A5

Rat IgG1κ

Recombinant mouse caspase-11 (p20 fragment).

ELISA: (recombinant protein)Flow Cytometry: (overexpressed in cell lines)Immunoprecipitation: (1-5μg/ml)Western Blot: (1-2μg/ml) Optimal conditions must be determined individually for each application.

MouseRat

Recognizes mouse and rat full-length caspase-11 protein. Detects two bands of ~38kDa and ~43kDa by Western blot.

≥95% (SDS-PAGE)

Protein G-affinity purified (sepharose column).

1mg/ml

Liquid. In PBS containing 0.02% sodium azide.

BLUE ICE

+4°C

-20°C

After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.

Stable for at least 1 year after receipt when stored at -20°C.

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Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7.

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