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Abeomics/Mouse Monoclonal Antibody to MCM2(Clone :BS18)/0.1 ml/10-12546

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¥9120.00
货号:10-12546
浏览量:127
品牌:Abeomics
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商品描述

Format :concentrate
Amount :0.5 ml
Content :TRIS with 0.03% sodium azide, pH7.2
Storage condition :Store at 4°C
Gene :MCM2
Gene ID :4171
Uniprot ID :P49736
Alternative Name :Minichromosome maintenance protein 2 homolog, Nuclear protein BM28, BM28, CCNL1, CDCL1, KIAA0030

Immunohistochemical Analysis :-1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:Nucleus
Post transnational modification:Phosphorylated on Ser-108 by ATR in proliferating cells. Ser-108 proliferation is increased by genotoxic agents. Ser-40 is mediated by the CDC7-DBF4 and CDC7-DBF4B complexes, while Ser-53 phosphorylation is only mediated by the CDC7-DBF4 complex. Phosphorylation by the CDC7-DBF4 complex during G1/S phase is required for the initiation of DNA replication.
BioGrid:110339.950 interactions.
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Abeomics的人PD-L1重组Fc融合蛋白(正在供货)CHO-K1 Celline。 PD-L1(CD274 / B7-H1)是一种重要的膜结合共刺激分子,属于B7超家族,可通过其受体抑制免疫反应,PD-1和PD-L1在炎症性疾病的发病机理中起关键作用死亡1)。它在单核吞噬细胞系统(MPS)中广泛表达,可共同刺激T细胞并调节炎症反应。PD-L1通过对T细胞功能产生负面共刺激作用来发挥炎症调节功能,以抑制细胞因子分泌,促进活化T细胞凋亡并诱导T细胞无反应。在细菌感染,炎症和许多自身免疫性疾病中,已经报道了CD274的异常表达和失调。