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蚂蚁淘在线 / 品牌中心 / Abeomics / Abeomics/Grazoprevir/5 mg/15-4003

Abeomics/Grazoprevir/5 mg/15-4003

价格
￥2400.00
货号：15-4003
浏览量：127
品牌：Abeomics
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Amount :10 mg
Purification :≥98%
Content :Grazoprevir is supplied as a crystalline solid.
Storage condition :Store at -20°C.
Alternative Name :MK-5172

Molecular Formula:C38H50N6O9S

Molecular Weight:766.9

Grazoprevir is a pan-genotypic protease inhibitor that binds to hepatitis C virus (HCV) non-structural protein 3/4A (NS3/4A), a serine protease essential for viral replication.Grazoprevir has potent in vitro activity against major HCV genotypes (Kis = 0.1, 0.1, 0.08, 0.15, and 0.9 nM for genotypes 1a, 1b, 2a, 2b, and 3a, respectively) and common resistance genotypes (Kis = 0.07, 0.14, and 0.30 nM for genotypes 1b R155K, D165V, and D168Y, respectively). Grazoprevir inhibits the NS3/4A protease in an in vitro replicon system with EC50 values of 2 and 8 nM for genotypes 1a and 2a, respectively. Formulations containing grazoprevir are used in combination therapies to treat HCV.

A stock solution may be made by dissolving the grazoprevir in the solvent of choice. Grazoprevir is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of grazoprevir in these solvents is approximately 15, 25, and 30 mg/ml, respectively.
Grazoprevir is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, grazoprevir should first be dissolved in DMF and then diluted with the aqueous buffer of choice. Grazoprevir has a solubility of approximately 0.2 mg/ml in a 1:4 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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Abeomics的人PD-L1重组Fc融合蛋白（正在供货）CHO-K1 Celline。 PD-L1（CD274 / B7-H1）是一种重要的膜结合共刺激分子，属于B7超家族，可通过其受体抑制免疫反应，PD-1和PD-L1在炎症性疾病的发病机理中起关键作用死亡1）。它在单核吞噬细胞系统（MPS）中广泛表达，可共同刺激T细胞并调节炎症反应。PD-L1通过对T细胞功能产生负面共刺激作用来发挥炎症调节功能，以抑制细胞因子分泌，促进活化T细胞凋亡并诱导T细胞无反应。在细菌感染，炎症和许多自身免疫性疾病中，已经报道了CD274的异常表达和失调。