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Kerafast/Anti-ADAM28 (mouse), Extracellular Domain Antibody/EHS012/100uL

价格
¥5980.00
货号:EHS012
浏览量:127
品牌:Kerafast
服务
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商品描述

ThisrabbitIgGpolyclonalantibodywasgeneratedagainsttheentireectodomainofADAM28includingtheEGFrepeatfusedtotheFcdomainofhumanIgGandisspecificfortheextracellulardomainofmouseADAM28.

TheADAM(ADisintegrinAndMetalloproteaseDomain)familyisauniquegroupofproteinsthathastheABIlitytocleaveorshedextracellularportionsoftransmembraneproteins.Inaddition,ADAMsareinvolvedincell-cellandcell-matrixinteractions(e.g.,fertilization,muscledevelopmentandneurogenesis).

Basedonsequenceidentity,ADAM28ismorecloselyrelatedtosnakevenommetalloproteases(SVMPs)thantopresentlyknownADAMs.NorthernblotanalysisrevealedADAM28isexpressedintheepididymis,suggestingapossIBLeroleinspermmaturation,andinthelung.MatureADAM28ispresumedtobecatalyticallyactiveandfoundmainlyonthecellsurface.

FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.

Specifications
ProductType: Antibody
AccessionID: AF153350
Antigen: GST-ADAM28CytoplasmicDomain
MolecularWeight: ~100kDa
Isotype: IgG
Clonality: Polyclonal
Reactivity: Mouse
Immunogen: EntireectodomainofmouseADAM28includingtheEGFrepeatfusedtotheFcdomainofhumanIgG1
SpeciesImmunized: Rabbit
Epitope: Extracellulardomain
PurificationMethod: Serum,notpurified
TestedApplications: WB(1:500),onlyonnon-reducedsamples(noDTTorBME)
Storage: -80C
Shipped: Dryice
Research
AntibodySpeciesReactivitySpecificity
ADAM9HumanCytoplasmicDomain
ADAM9MouseCytoplasmicDomain
ADAM12MouseCytoplasmicDomain
ADAM15HumanCytoplasmicDomain
ADAM15MouseCytoplasmicDomain
ADAM15HumanExtracellularDomain
ADAM15MouseDisintegrinDomain
ADAM17MouseCytoplasmicDomain
ADAM17MouseProdomain
ADAM19MouseCytoplasmicDomain
ADAM28MouseCytoplasmicDomain
ADAM28MouseExtracellularDomain
SNX9MouseCytoplasmicDomain
Provider
FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.
References
  1. Howard,L.;Zheng,Y.;Horrocks,M.;Maciewicz,R.A.;Blobel,C.CatalyticactivityofADAM28.FEBSLett.2001,498,82-86.

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抗DNA-RNA杂合体[S9.6]抗体 Anti-DNA-RNA Hybrid [S9.6] Antibody   针对ΦX174噬菌体衍生的合成DNA-RNA抗原产生该小鼠单克隆抗体,并识别各种长度的RNA-DNA杂交体。 强调: 对DNA-RNA杂交体具有高度特异性和亲和力 可用于检测R环 不与单链DNA或双链DNA交叉反应 对于富含AU的双链RNA,已观察到轻微的交叉反应(约5倍)。 对于长度为8,10,15和23个碱基对的杂交体显示出高亲和力结合 DNA-RNA杂合体是真核细胞中的天然存在,这些za种的水平在具有高转录活性的位点增加,例如在转录起始,抑制和延伸期间。由于RNA-DNA杂交体影响基因组不稳定性,S9.6抗体是一种有用的试剂,可帮助研究这些za种在DNA复制或其他细胞过程中形成的R环和损伤的后果。此外,S9.6抗体可有效识别用于微阵列研究的RNA-DNA杂交。 来自国家过敏和传染病研究所/ NIH 的Stephen H. Leppla博士实验室。 C货号 品名 规格 ENH001 Anti-DNA-RNA Hybrid [S9.6] Antibody, 100ug 100ug ENH002 Anti-DNA-RNA Hybrid [S9.6] Antibody, 1mg (10x100ug) 1mg (10x100ug)