ThisrabbitIgGpolyclonalantibodywasgeneratedagainstanextracellulardomainfusionproteinofhumanADAM15withanIgGFcdomainandisspecificfortheextracellulardomainofhumanADAM15.
TheADAM(ADisintegrinAndMetalloproteaseDomain)familyisauniquegroupofproteinsthathastheABIlitytocleaveorshedextracellularportionsoftransmembraneproteins.Inaddition,ADAMsareinvolvedincell-cellandcell-matrixinteractions(e.g.,fertilization,muscledevelopmentandneurogenesis).
ADAM15(Metargidin)isamembrane-anchoredglycoproteinthathasbeenimplicatedinpathologicalneovascularizationandprostatecancermetastasis.
FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.
PartofTheInvestigator"sAnnexeprogram.
ProductType: | Antibody |
AccessionID: | NM_009614 |
Antigen: | ADAM15ExtracellularDomainwithIgGFcDomain |
MolecularWeight: | ~100kDa |
Isotype: | IgG |
Clonality: | Polyclonal |
Reactivity: | Human |
Immunogen: | ExtracellularDomainfusionproteinofhumanADAM15withanIgGFcDomain |
SpeciesImmunized: | Rabbit |
Epitope: | Extracellulardomain |
PurificationMethod: | Serum,notpurified |
TestedApplications: | Westernblot,onlyworksonnon-reducedsamples(noDTTorBME)1:500 |
Storage: | -80C |
Shipped: | Dryice |
Antibody | SpeciesReactivity | Specificity |
ADAM9 | Human | CytoplasmicDomain |
ADAM9 | Mouse | CytoplasmicDomain |
ADAM12 | Mouse | CytoplasmicDomain |
ADAM15 | Human | CytoplasmicDomain |
ADAM15 | Mouse | CytoplasmicDomain |
ADAM15 | Human | ExtracellularDomain |
ADAM15 | Mouse | DisintegrinDomain |
ADAM17 | Mouse | CytoplasmicDomain |
ADAM17 | Mouse | Prodomain |
ADAM19 | Mouse | CytoplasmicDomain |
ADAM28 | Mouse | CytoplasmicDomain |
ADAM28 | Mouse | ExtracellularDomain |
SNX9 | Mouse | CytoplasmicDomain |
- Krätzschmar,J.;Lum,L.;Blobel,C.P.Metargidin,amembrane-anchoredmetalloprotease-disintegrinproteinwithanRGDintegrinbindingsequence.J.Biol.Chem.1996,271,4593-4596.
- Horiuchi,K.;Weskamp,G.;Lum,L.;Hammes,H.P.;Cai,H.;Brodie,T.A.;Ludwig,T.;Chiusaroli,R.;Baron,R.;Preissner,K.T.;Manova,K.;Blobel,C.P.PotentialroleforADAM15inpathologicalneovascularizationinmice.Mol.Cell.Biol.2003,23,5614-5624.
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