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4000-520-616 / 18915418616
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0512-67156496
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商品描述
Rb (phospho-Ser807/811)rabbit pAb
- Catalog No.：YP1462
- Applications：WB
- Reactivity：Human,Mouse,Rat
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- Gene Name：
- RB1
- Protein Name：
- Rb (Ser807/811)
- Human Gene Id：
- 5925
- Human Swiss Prot No：
- P06400
- Mouse Gene Id：
- 19645
- Mouse Swiss Prot No：
- P13405
- Rat Gene Id：
- 24708
- Rat Swiss Prot No：
- P33568
- Immunogen：
- Synthesized phosho peptide around human Rb (Ser807 and 811)
- Specificity：
- This antibody detects endogenous levels ofHuman Mouse Rat Rb (phospho-Ser807 or 811)
- Formulation：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source：
- Rabbit
- Dilution：
- WB 1:1000-2000
- Purification：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration：
- 1 mg/ml
- Storage Stability：
- -20°C/1 year
- Other Name：
- Retinoblastoma-associated protein (p105-Rb) (pRb) (Rb) (pp110)
- Observed Band(KD)：
- 106
- Background：
- RB transcriptional corepressor 1(RB1) Homo sapiensThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],
- Function：
- disease:Defects in RB1 are a cause of bladder cancer [MIM:109800].,disease:Defects in RB1 are a cause of osteogenic sarcoma [MIM:259500].,disease:Defects in RB1 are the cause of childhood cancer retinoblastoma (RB) [MIM:180200]. RB is a congenital malignant tumor that arises from the nuclear layers of the retina. It occurs in about 1:20"000 live births and represents about 2% of childhood malignancies. It is bilateral in about 30% of cases. Although most RB appear sporadically, about 20% are transmitted as an autosomal dominant trait with incomplete penetrance. The diagnosis is usually made before the age of 2 years when strabismus or a gray to yellow reflex from pupil ("cat eye") is investigated.,function:Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts
- Subcellular Location：
- chromatin,nucleus,nucleoplasm,spindle,cyclin/CDK positive transcription elongation factor complex,SWI/SNF complex,PML body,Rb-E2F complex,
- Expression：
- Brain,Carcinoma,Cervix,Peripheral blood,Testis,
- June 19-2018
- WESTERN IMMUNOBLOTTING PROTOCOL
- June 19-2018
- IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL
- June 19-2018
- IMMUNOFLUORESCENCE PROTOCOL
- June 19-2018
- FLOW CYTOMEYRT PROTOCOL
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN
- July 13-2018
- CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN
- July 13-2018
- Antibody-FAQs
