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蚂蚁淘在线 / 品牌中心 / Immunoway / Immunoway/Tuberin/TSC2 (phospho-Ser664) rabbit pAb/20ug 50ug 100ug/YP1540
商品描述
Tuberin/TSC2 (phospho-Ser664)rabbit pAb
- Catalog No.：YP1540
- Applications：WB
- Reactivity：Human
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- Gene Name：
- TSC2 TSC4
- Protein Name：
- Tuberin/TSC2 (Ser664)
- Human Gene Id：
- 7249
- Human Swiss Prot No：
- P49815
- Mouse Swiss Prot No：
- Q61037
- Rat Gene Id：
- 24855
- Rat Swiss Prot No：
- P49816
- Immunogen：
- Synthesized phosho peptide around human Tuberin (Ser664)
- Specificity：
- This antibody detects endogenous levels ofHuman Tuberin/TSC2 (phospho-Ser664)
- Formulation：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source：
- Rabbit
- Dilution：
- WB 1:1000-2000
- Purification：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration：
- 1 mg/ml
- Storage Stability：
- -20°C/1 year
- Other Name：
- Tuberin (Tuberous sclerosis 2 protein)
- Observed Band(KD)：
- 200
- Background：
- tuberous sclerosis 2(TSC2)Homo sapiensMutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
- Function：
- alternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms,disease:Defects in TSC2 are a cause of lymphangioleiomyomatosis (LAM) [MIM:606690]. LAM is a progressive and often fatal lung disease characterized by a diffuse proliferation of abnormal smooth muscle cells in the lungs. It affects almost exclusively young women and can occur as an isolated disorder or in association with tuberous sclerosis complex.,disease:Defects in TSC2 are the cause of tuberous sclerosis complex (TSC) [MIM:191100]. The molecular basis of TSC is a functional impairment of the tuberin-hamartin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. TSC is characterized by hamartomas (benign overgrowths predominantly of a cell or tissue type that occurs normally in the organ) and hamartias (de
- Subcellular Location：
- nucleus,cytoplasm,lysosome,Golgi apparatus,cytosol,membrane,TSC1-TSC2 complex,perinuclear region of cytoplasm,
- Expression：
- Blood,Brain,Endometrium,Epithelium,Lymph,Lymphoblast,Peripheral blood leukocyte,Pla
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