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4000-520-616 / 18915418616
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0512-67156496
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商品描述
Numb (phospho-Ser276)rabbit pAb
- Catalog No.：YP1424
- Applications：WB
- Reactivity：Human
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- Gene Name：
- NUMB
- Protein Name：
- Numb (Ser276)
- Human Gene Id：
- 8650
- Human Swiss Prot No：
- P49757
- Mouse Gene Id：
- 18222
- Mouse Swiss Prot No：
- Q9QZS3
- Rat Swiss Prot No：
- Q2LC84
- Immunogen：
- Synthesized phosho peptide around human Numb (Ser276)
- Specificity：
- This antibody detects endogenous levels ofHuman Numb (phospho-Ser276)
- Formulation：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source：
- Rabbit
- Dilution：
- WB 1:1000-2000
- Purification：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration：
- 1 mg/ml
- Storage Stability：
- -20°C/1 year
- Other Name：
- Protein numb homolog (h-Numb) (Protein S171)
- Observed Band(KD)：
- 70
- Background：
- NUMB, endocytic adaptor protein(NUMB) Homo sapiensThe protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
- Function：
- function:Implicated in the control of cell fate decisions during development.,PTM:Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.,sequence caution:Intron retention.,similarity:Contains 1 PID domain.,subunit:Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.,
- Subcellular Location：
- nucleus,early endosome,plasma membrane,cell-cell adherens junction,focal adhesion,cytoplasmic, membrane-bounded vesicle,basolateral plasma membrane,extrinsic component of plasma membrane,clathrin-coated vesicle,apical part of cell,
- Expression：
- B cells,Blood,Brain,Cervix carcinoma,Epithelium,Fetal brain,HeLa cells,Live
- June 19-2018
- WESTERN IMMUNOBLOTTING PROTOCOL
- June 19-2018
- IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL
- June 19-2018
- IMMUNOFLUORESCENCE PROTOCOL
- June 19-2018
- FLOW CYTOMEYRT PROTOCOL
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN
- July 13-2018
- CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN
- July 13-2018
- Antibody-FAQs
