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商品描述
Keratin 20 (phospho-Ser13)rabbit pAb
- Catalog No.：YP1378
- Applications：WB
- Reactivity：Human
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- Gene Name：
- KRT20
- Protein Name：
- Keratin 20 (Ser13)
- Human Gene Id：
- 54474
- Human Swiss Prot No：
- P35900
- Mouse Gene Id：
- 66809
- Mouse Swiss Prot No：
- Q9D312
- Rat Gene Id：
- 286912
- Rat Swiss Prot No：
- P25030
- Immunogen：
- Synthesized phosho peptide around human Keratin 20 (Ser13)
- Specificity：
- This antibody detects endogenous levels ofHuman Keratin 20 (phospho-Ser13)
- Formulation：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source：
- Rabbit
- Dilution：
- WB 1:1000-2000
- Purification：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration：
- 1 mg/ml
- Storage Stability：
- -20°C/1 year
- Other Name：
- Keratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20) (K20) (Protein IT)
- Observed Band(KD)：
- 49
- Background：
- keratin 20(KRT20) Homo sapiensThe protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008],
- Function：
- developmental stage:First detected at embryonic week 8 in individual "converted" simple epithelial cells of the developing intestinal mucosa. In later fetal stages, synthesis extends over most goblet cells and a variable number of villus enterocytes. In the developing gastric and intestinal mucosa, expressed in all enterocytes and goblet cells as well as certain "low-differentiated" columnar cells, whereas the neuroendocrine and Paneth cells are negative.,function:Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during t
- Subcellular Location：
- cytoplasm,intermediate filament,
- Expression：
- Intestine,Small intestine,
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- Antibody-FAQs
