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商品描述
Tyk2 (phospho-Tyr1054/1055)rabbit pAb
- Catalog No.：YP1541
- Applications：WB
- Reactivity：Human
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- Gene Name：
- TYK2
- Protein Name：
- Tyk2 (Tyr1054/1055)
- Human Gene Id：
- 7297
- Human Swiss Prot No：
- P29597
- Mouse Swiss Prot No：
- Q9R117
- Immunogen：
- Synthesized phosho peptide around human Tyk2 (Tyr1054 and 1055)
- Specificity：
- This antibody detects endogenous levels ofHuman Tyk2 (phospho-Tyr1054 or 1055)
- Formulation：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source：
- Rabbit
- Dilution：
- WB 1:1000-2000
- Purification：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration：
- 1 mg/ml
- Storage Stability：
- -20°C/1 year
- Other Name：
- Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)
- Observed Band(KD)：
- 134
- Background：
- tyrosine kinase 2(TYK2) Homo sapiensThis gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008],
- Function：
- catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also called autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. The syndrome consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.,domain:The FERM domain mediates interaction with JAKMIP1.,function:Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.,online information:TYK2 mutation db,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,similarity:Conta
- Subcellular Location：
- nucleus,cytoplasm,cytosol,cytoskeleton,membrane,extrinsic component of cytoplasmic side of plasma membrane,extracellular exosome,
- Expression：
- Brain,Kidney,
- June 19-2018
- WESTERN IMMUNOBLOTTING PROTOCOL
- June 19-2018
- IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL
- June 19-2018
- IMMUNOFLUORESCENCE PROTOCOL
- June 19-2018
- FLOW CYTOMEYRT PROTOCOL
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN
- July 13-2018
- CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN
- July 13-2018
- Antibody-FAQs
