1-Methylhistamine ELISA Assay Kit
1-Methylhistamine ELISA Assay Kit Developed and Manufactured in Germany by DLD Diagnostika EA208/96
Size: 1×96 wells
Sensitivity: Urine: 2.5 ng/ml, Plasma/Cell Culture: 0.13 ng/ml
Dynamic Range: Urine: 10 -1000 ng/ml, Plasma/Cell Culture: 0.2 – 20 ng/ml
Incubation Time: Overnight
Sample Type: Urine, Plasma, Cell Culture
Sample Size: 20 µL
For Research Use Only
Controls Included
Conversion factor:
1-Methylhistamine: 1 ng / ml = 8.0 nmol / l
Assay Background
The Eagle Biosciences 1-Methylhistamine ELISA Assay kit is an Enzyme-linked immunosorbent assay used for the quantitative and very sensitive determination of 1-Methylhistamine in biological samples including urine, plasma, and cell culture samples. The 1-Methylhistamine ELISA Assay kit is for research use only and should not be used in diagnostic procedures. Histamine (β-imidazole-ethylamine) a biogenic amine and is a product of the histidine metabolism. It is produced by decarboxylation of histidine. Histamine is widely distributed in mammalian tissues. It is bound to heparin (as inactive form) and stored in the granules of basophilic leukocytes and mast cells and is actively released as required. These cells, if sensitized by IgE antibodies attached to their membranes, degranulate when exposed to the appropriate antigen. Histamine plays a major rule in the initial phase of an anaphylactic reaction. The quantification of histamine in plasma after allergen administration is of clinical interest.
Histamine is part of the immune response to foreign pathogens and it increases the permeability of the capillaries to white blood cells and other proteins, in order to allow them to engage foreign invaders in the affected tissues. 1-Methylhistamine is a histamine metabolite. It is a product of histamine 1- methyltransferase. Urinary histamine and 1-methylhistamine are highly correlated with histamine in plasma. Therefore, allergic reactions can be examined by determination of histamine and 1-methylhistamine in urine.
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EagleBio的5α-雄甾烷-3α，17β-二醇葡糖醛酸化物是C19类固醇，缩写为3α-DiolG，5α二醇G或简称为α二醇G。它主要作为睾丸激素和二氢睾丸激素（DHT）的代谢产物生产。它主要在目标外围组织（例如皮肤）中产生，尤其是在毛囊周围。大量的3α-DiolG刺激会导致过多的头发形成，特别是在女性通常不存在头发的地方。近年来，在研究患有特发性多毛症的妇女的临床研究人员中，人们对这种类固醇的测量越来越感兴趣。已知是3α-DiolG前体的类固醇包括脱氢表雄酮（DHEA），硫酸脱氢表雄酮（DHEAS），二氢睾丸酮（DHT），雄烯二酮和睾丸激素。已显示只有3α-DiolG随多毛症增加而随治疗减少。这种相关性在多囊卵巢综合征（PCO）患者中也得到了证明。3α-DiolG的测定因此被证明是多种方式的有用指标，包括监测特发性多毛症和PCO妇女的治疗进展。此外，接受环孢霉素A治疗的糖尿病患者（无论男女）均显示3α-DiolG水平升高，这种副作用导致以前无毛的区域出现了头发。3α-DiolG的测定因此被证明是多种方式的有用指标，包括监测特发性多毛症和PCO妇女的治疗进展。此外，接受环孢霉素A治疗的糖尿病患者（无论男女）均显示3α-DiolG水平升高，这种副作用导致以前无毛的区域出现了头发。3α-DiolG的测定因此被证明是多种方式的有用指标，包括监测特发性多毛症和PCO妇女的治疗进展。此外，接受环孢霉素A治疗的糖尿病患者（无论男女）均显示3α-DiolG水平升高，这种副作用导致以前无毛的区域出现了头发。
