Homocysteine HPLC Assay Column

The Homocysteine HPLC Assay Column is For Research Use Only

Each column is can be utilized for approximately 500-1000 samples depending on column care and sample type.

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Assay Background

Homocysteine is an amino acid, which is produced out of methionine. It is not ingested by nutrition. Homocysteine is rapidly degraded to cysteine when vitamin B6, folic acid and vitamin B12 are sufficiently available. Increased levels of homocysteine will damage heart and blood vessels. Meanwhile it is an established risk marker for cardiovascular disease. US studies demonstrate that 40% of heart attacks are caused by increased homocysteine levels. Also the risk for stroke is increased by elevated homocysteine concentrations in plasma. A participation of homocysteine in Alzheimer and Parkinson diseases are under discussion.

The reason for high homocysteine levels are a lack of vitamin B6, folic acid and vitamin B12 and/or a defect in the enzyme cystathione synthase, which catalysis the reaction from homocysteine to cysteine.  Increased homocysteine concentration have been found to be reduced by the supplementation with folic acid, vitamin B6 and vitamin B12.

The Eagle Biosciences Homocysteine HPLC Assay Kit makes it possible to determine homocysteine in an easy, fast and precise method. The Homocysteine HPLC Assay kit includes all reagents for preparation and separation of the samples with exception of the columns (IC2801rp) and the controls (IC2801ko). Both can be supplied by Eagle Biosciences.  Beside the complete test kits it is possible to order all components separately. Please request our single component price list.

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EagleBio的5α-雄甾烷-3α，17β-二醇葡糖醛酸化物是C19类固醇，缩写为3α-DiolG，5α二醇G或简称为α二醇G。它主要作为睾丸激素和二氢睾丸激素（DHT）的代谢产物生产。它主要在目标外围组织（例如皮肤）中产生，尤其是在毛囊周围。大量的3α-DiolG刺激会导致过多的头发形成，特别是在女性通常不存在头发的地方。近年来，在研究患有特发性多毛症的妇女的临床研究人员中，人们对这种类固醇的测量越来越感兴趣。已知是3α-DiolG前体的类固醇包括脱氢表雄酮（DHEA），硫酸脱氢表雄酮（DHEAS），二氢睾丸酮（DHT），雄烯二酮和睾丸激素。已显示只有3α-DiolG随多毛症增加而随治疗减少。这种相关性在多囊卵巢综合征（PCO）患者中也得到了证明。3α-DiolG的测定因此被证明是多种方式的有用指标，包括监测特发性多毛症和PCO妇女的治疗进展。此外，接受环孢霉素A治疗的糖尿病患者（无论男女）均显示3α-DiolG水平升高，这种副作用导致以前无毛的区域出现了头发。3α-DiolG的测定因此被证明是多种方式的有用指标，包括监测特发性多毛症和PCO妇女的治疗进展。此外，接受环孢霉素A治疗的糖尿病患者（无论男女）均显示3α-DiolG水平升高，这种副作用导致以前无毛的区域出现了头发。3α-DiolG的测定因此被证明是多种方式的有用指标，包括监测特发性多毛症和PCO妇女的治疗进展。此外，接受环孢霉素A治疗的糖尿病患者（无论男女）均显示3α-DiolG水平升高，这种副作用导致以前无毛的区域出现了头发。