Phenylalanine, Tyrosine & Tryptophan HPLC Column

The Phenylalanine, Tyrosine & Tryptophan HPLC Column is For Research Use Only

Each column is can be utilized for approximately 500-1000 samples depending on column care and sample type.

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Assay Background

Phenylketonuria is the most abundant genetic disorder of the amino acid metabolism. It is characterized by a lack of phenylalanine hydroxylase which causes an increase of phenylalanine in cells and body fluids.  Due to the lack of enzyme activity, phenylalanine, normally metabolised to tyrosine, is converted to phenylpyruvic acid.  Left untreated, this can cause brain damage and progressive mental retardation. Additionally high concentrations of phenylalanine inhibit various enzymes which are involved in the synthesis of neurotransmitters and melanin. The incidence of occurrence is about 1 in 15000, varying widely in different populations.
Untreated children with phenylketonuria are normal at birth, but rather early they don´t attain early developmental milestones, show mental retardation, hyperactivity, convulsions, low pigmentation of the hair and alterations of the skin.  An early diagnosis within the first days after birth is very important. Nevertheless the blood level of phenylalanine has to be controlled regularly because reduced levels can lead to proteolysis with disturbance of growth.
The Eagle Biosciences Phenylalanine, Tyrosine & Tryptophan HPLC Assay kit makes it possible to determine phenylalanine, tyrosine and tryptophan in an easy, fast and precise method. The Phenylalanine, Tyrosine & Tryptophan HPLC Assay kit includes all reagents for preparation and separation of the samples with exception of the columns (IC4000rp) and the controls (IC4000ko). Both can be supplied by Eagle Biosciences.  Besides the complete test kits it is possible to order all components separately.  Please request our single component price list.

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EagleBio的5α-雄甾烷-3α，17β-二醇葡糖醛酸化物是C19类固醇，缩写为3α-DiolG，5α二醇G或简称为α二醇G。它主要作为睾丸激素和二氢睾丸激素（DHT）的代谢产物生产。它主要在目标外围组织（例如皮肤）中产生，尤其是在毛囊周围。大量的3α-DiolG刺激会导致过多的头发形成，特别是在女性通常不存在头发的地方。近年来，在研究患有特发性多毛症的妇女的临床研究人员中，人们对这种类固醇的测量越来越感兴趣。已知是3α-DiolG前体的类固醇包括脱氢表雄酮（DHEA），硫酸脱氢表雄酮（DHEAS），二氢睾丸酮（DHT），雄烯二酮和睾丸激素。已显示只有3α-DiolG随多毛症增加而随治疗减少。这种相关性在多囊卵巢综合征（PCO）患者中也得到了证明。3α-DiolG的测定因此被证明是多种方式的有用指标，包括监测特发性多毛症和PCO妇女的治疗进展。此外，接受环孢霉素A治疗的糖尿病患者（无论男女）均显示3α-DiolG水平升高，这种副作用导致以前无毛的区域出现了头发。3α-DiolG的测定因此被证明是多种方式的有用指标，包括监测特发性多毛症和PCO妇女的治疗进展。此外，接受环孢霉素A治疗的糖尿病患者（无论男女）均显示3α-DiolG水平升高，这种副作用导致以前无毛的区域出现了头发。3α-DiolG的测定因此被证明是多种方式的有用指标，包括监测特发性多毛症和PCO妇女的治疗进展。此外，接受环孢霉素A治疗的糖尿病患者（无论男女）均显示3α-DiolG水平升高，这种副作用导致以前无毛的区域出现了头发。