Recombinant Human His6-HR23A/Rad23A Tandem UBA (TUBE1), CF Summary
Human HR23A/Rad23A has two Ubiquitin-associated (UBA) motifs that can each bind Ubiquitin via a hydrophobic surface formed by residues located within thealpha 1 andalpha 3 helices of each UBA domain (1,2). Tandem-repeated Ubiquitin binding entities (TUBEs), which consist of multiple tandem Ubiquitin-binding UBA motifs,have been developed for the isolation and identification of ubiquitinated proteins (3). TUBEs show increased affinity for poly-Ubiquitin moieties compared to single UBA motifs (4). Additionally, TUBEs protect polyubiquitinated proteins from deubiquitylating enzymes, allowing for the detection of polyubiquitinated proteins at relatively low levels of abundance (5).
This protein is His6-tagged which allows for metal chelate affinity purification and also allows for convenient immuno-detection of conjugates using His6-specific antibodies.
Specifications
- 12 months from date of receipt, -70 °C as supplied.
- 3 months, -70 °C under sterile conditions after opening.
Product Datasheets
Background: HR23A/Rad23A TUBE1
Reagents Provided
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