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OTU Domain-containing Protein 7B; Cellular Zinc Finger anti-NF-κ-B Protein; Zinc Finger A20 Domain-containing Protein 1; ZA20D1

Protein

E. coli

Human OTUD7B (catalytic domain, including the OTU domain aa 167-440) (Accession Nr. Q6GQQ9).

Human

Liquid. In 50mM HEPES pH 7.5, 100mM NaCl, 10% Glycerol (v/v), 1mM TCEP.

Use: Ubiquitin-specific deconjugating enzyme. Reaction conditions will need to be optimized for each specific application. We recommend an initial protein concentration of 0.1-1µM.

Manufactured by Boston Biochem

DRY ICE

-20°C

-80°C

Aliquot to avoid freeze/thaw cycles.

Stable for at least 1 year after receipt when stored at -80°C.

No

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OTU domain-containing protein 7B (OTUD7B), also known as Cezanne, is a C64 type peptidase and a member of the ovarian tumor (OTU) protein super-family with a predicted molecular weight of 93 kDa. The human protein shares 90% amino acid sequence identity with its mouse ortholog. Cezanne has been reported to cleave K48-, and K63-linked poly-ubiquitin chains and also to display a preference for K11-linked chains. It has been shown to play a role in the negative regulation of NF-κB signaling, possibly by deubiquitination of RIPK1 and TRAF3.

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