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蚂蚁淘在线 / 品牌中心 / Boston Biochem / Boston Biochem/Z-VAD-FMK/2163/1

Boston Biochem/Z-VAD-FMK/2163/1

价格
￥5020.00
货号：2163/1
浏览量：117
品牌：Boston Biochem
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商品描述
Product Details
Citations (32)
Reviews (3)
Biological Activity Technical DataBackground Product DatasheetsCalculators

Biological Activity

Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

Technical Data

M.Wt:
467.49
Formula:
C22H30FN3O7
Sequence:
VAD

(Modifications: Val-1 = Z-Val, Asp-3 = (OMe)-fluoromethylketone)

Solubility:
Soluble to 9.35 mg/ml in DMSO
Storage:
Store at -20°C
CAS No:
187389-52-2

The technical data provided above is for guidance only.For batch specific data refer to the Certificate of Analysis.Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32.Slee et al.Biochem.J., 1996;315:21
  2. ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-α.Kunstle et al.Immunol.Lett., 1997;55:5
  3. Inhibition of human caspases by peptide-based and macromolecular inhibitors.Garcia-Calvo et al.J.Biol.Chem., 1998;273:32608
  4. Processing/activation of caspases, -3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lyphocytic leukemia cells.King et al.Leukemia, 1998;12:1553

Product Datasheets

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Citations for Z-VAD-FMK

The citations listed below are publications that use Tocris products.Selected citations for Z-VAD-FMK include:

32Citations: Showing 1 - 10

  1. Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes.Authors: Bae Et al.Cells2019;8
  2. Necroptosis in primate luteolysis: a role for ceramide.Authors: Bagnjuk Et al.Cell Death Discov2019;5:67
  3. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.Authors: Uderhardt Et al.Cell2019;177:541
  4. ONC201 kills breast cancer cells in vitro by targeting mitochondria.Authors: Greer Et al.Oncotarget2018;9:18454
  5. Phosphatidylserine is a marker for axonal debris engulfment but its exposure can be decoupled from degeneration.Authors: Shacham-Silverberg Et al.Cell Death Dis2018;9:1116
  6. US6 Gene Deletion in Herpes Simplex Virus Type 2 Enhances Dendritic Cell Function and T Cell Activation.Authors: Retamal-Díaz Et al.Front Immunol2017;8:1523
  7. Methylsulfonylmethane Induces p53 Independent Apoptosis in HCT-116 Colon Cancer CellsAuthors: Karabay Et al.International Journal of Molecular Sciences2016;17:1123
  8. Guadecitabine (SGI-110) priming sensitizes hepatocellular carcinoma cells to oxalip.Authors: Kuang Et al.Mol Oncol2015;9:1799
  9. The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.Authors: Baron Et al.Mol Cell Biol2015;6:e1629
  10. NF-κB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancer.Authors: Hu Et al.Clin Cancer Res2015;35:379
  11. Sorafenib induces cathepsin B-mediated apoptosis of bladder cancer cells by regulating the Akt/PTEN pathway. The Akt inhibitor, perifosine, enhances the sorafenib-induced cytotoxicity against bladder cancer cells.Authors: Amantini Et al.Cell Death Dis2015;2:395
  12. Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation.Authors: Bonnefond Et al.Oncoscience2015;20:535
  13. Human ACAP2 is a homolog of C. elegans CNT-1 that promotes apoptosis in cancer cells.Authors: Sullivan Et al.Cell Cycle2015;14:1771
  14. A delay prior to mitotic entry triggers caspase 8-dependent cell death in p53-deficient Hela and HCT-116 cells.Authors: Silva Et al.Apoptosis2015;14:1070
  15. mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation.Authors: Moon Et al.Cell Rep2015;12:102
  16. Recombinant adeno-associated virus utilizes host cell nuclear import machinery to enter the nucleus.Authors: NicolsonJ Virol2014;88:4132
  17. The ethyl acetate fraction of Sargassum muticum attenuates ultraviolet B radiation-induced apoptotic cell death via regulation of MAPK- and caspase-dependent signaling pathways in human HaCaT keratinocytes.Authors: Piao Et al.Pharm Biol2014;52:1110
  18. Parasympathetic innervation regulates tubulogenesis in the developing salivary gland.Authors: Nedvetsky Et al.Dev Cell2014;30:449
  19. A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells.Authors: Hight Et al.Evid Based Complement Alternat Med2014;20:2126
  20. The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells.Authors: Sagher Et al.Cancer Cell Int2014;14:75
  21. Role of ROS and HMGB1 in contact allergen-induced IL-18 production in human keratinocytes.Authors: Galbiati Et al.J Invest Dermatol2014;134:2719
  22. The mTORC2 component rictor contributes to cisp. resistance in human ovarian cancer cells.Authors: Im-aram Et al.PLoS One2013;8:e75455
  23. A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells.Authors: Kim Et al.Cell Death Dis2013;4:e750
  24. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.Authors: Jahchan Et al.Cancer Discov2013;3:1364
  25. Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro.Authors: Wang Et al.Mar Drugs2013;2013:857929
  26. Cytotoxic effect of clerosterol isolated from Codium fragile on A2058 human melanoma cells.Authors: Kim Et al.Mol Cancer Res2013;11:418
  27. Annexin A1 modulates natural and glucocorticoid-induced resolution of inflammation by enhancing neutrophil apoptosis.Authors: Vago Et al.J Leukoc Biol2012;92:249
  28. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.Authors: Sullivan Et al.Cell Cycle2012;8:646
  29. Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness.Authors: Cook Et al.Oncotarget2012;72:3337
  30. Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking.Authors: Woo Et al.J Biol Chem2012;287:3963
  31. GS28 Protects Neuronal Cell Death Induced by Hydrogen Peroxide under Glutathione-Depleted Condition.Authors: Lee Et al.Korean J Physiol Pharmacol2011;15:149
  32. Glioma regression in vitro and in vivo by a suicide combined treatment.Authors: García-Escudero Et al.Cancer Res2008;6:407

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Reviews for Z-VAD-FMK

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Used for FACS
By Anonymouson 06/06/2020
Application: Species:Mouse

25 μM

It blocks caspases activity in cultured microglia
By Anonymouson 09/27/2019
Application: Species:Rat

We pretreated to cultured microglia to inhibit caspases activity at 20microM

Caspase inhibitor
By ParamanandaSaikiaon 01/04/2018
Application: Species:Mouse

AML12 hepatocytes were cultured and were per-treated withZ-VAD-FMK.

Boston Biochem波士顿生物化学已与IQ Proteomics™合作，为分析您的泛素化蛋白提供定制服务。使用哈佛医学院Gygi实验室开发的泛素绝对定量（AQUA）技术，我们可以对样品中存在的不同泛素连接进行定量表征。