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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
Biological Activity Technical DataBackground Product DatasheetsCalculators
Biological Activity
Antifungal and immunosuppressant. Specific inhibitor of mTOR (mammalian target of Rapamycin). Complexes with FKBP-12 and binds mTOR inhibiting its activity. Inhibits interleukin-2-induced phosphorylation and activation of p70 S6 kinase. Induces autophagy in yeast and mammalian cell lines. Drives hPSC differentiation to mesendoderm and blood progenitor cells. Also used as a chemical dimerizer; rapamycin and GA3-AM (Cat. No. 5407) chemically inducible dimerization systems are orthogonal. Inhibits MERS-CoV infection of Huh7 cells in a plaque reduction assay.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Rapamycin is reviewed on the chemical probes website.Technical Data
M.Wt:
914.18
Formula:
C51H79NO13
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
53123-88-9
The technical data provided above is for guidance only.For batch specific data refer to the Certificate of Analysis.Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
- Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.Galluzzi et al.Nat.Rev.Drug.Discov., 2017;
- Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase.Kuo et al.Nature, 1992;358:70
- Rapamycins: mechanism of action and cellular resistance.Huang et al.Cancer Biol.Ther., 2003;2:221
- Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis.Kobayashi et al.Cancer Sci., 2007;98:726
- A multi-lineage screen reveals mTORC1 inhibition enhances human pluripotent stem cell mesendoderm and blood progenitor production.Nazareth et al.Stem Cell Reports, 2016;6:679
- Rapid and orthogonal logic gating with a gibberellin-induced dimerization systemMiyamoto et al.Nat.Chem.Biol., 2012;8:465
- Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East Respiratory Syndrome coronavirus infection as identified by temporal kinome analysis.Kindrachuk et al.Antimicrob.Agents Chemother., 2015;59:1088
Product Datasheets
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Citations for Rapamycin
The citations listed below are publications that use Tocris products.Selected citations for Rapamycin include:
48Citations: Showing 1 - 10
- Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression.Authors: Anelli Et al.Front Genet2019;9:675
- Direct Gαq Gating Is the Sole Mechanism for TRPM8 Inhibition Caused by Bradykinin Receptor Activation.Authors: ZhangCell Rep2019;27:3672
- Melatonin: The smart molecule that differentially modulates autophagy in tumor and normal placental cells.Authors: Sagrillo-Fagundes Et al.PLoS One2019;14:e0202458
- Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons.Authors: Livingstone Et al.Front Mol Neurosci2019;12:198
- Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism.Authors: Lancaster Et al.Cell Metab2018;27:1096
- Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells.Authors: Li Et al.Endocrinology2018;159:285
- Eicosapentaenoic acid attenuates dexamethasome-induced apoptosis by inducing adaptive autophagy via GPR120 in murine bone marrow-derived mesenchymal stem cells.Authors: Gao Et al.Cell Death Dis2016;7:e2235
- Vitamin C alleviates aging defects in a stem cell model for Werner syndrome.Authors: Li Et al.Protein Cell2016;7:478
- Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.Authors: Jennewein Et al.Oncotarget2016;7:20016
- Activation of the Mammalian Target of Rapamycin in the Rostral Ventromedial Medulla Contributes to the Maintenance of Nerve Injury-Induced Neuropathic Pain in Rat.Authors: Wang Et al.Neural Plast2016;2015:394820
- Bone morphogenetic protein dominantly suppresses epidermal growth factor-induced proliferative expansion of adult forebrain neural precursors.Authors: Joppé Et al.Nat Cell Biol2015;9:407
- Modulation of BK channels contributes to activity-dependent increase of excitability through MTORC1 activity in CA1 pyramidal cells of mouse hippocampus.Authors: Springer Et al.Mol Biol Cell2015;8:451
- PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex.Authors: Alves Et al.Front Cell Neurosci2015;5:14534
- GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling.Authors: Stretton Et al.Front Neurosci2015;470:207
- A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells.Authors: López-Cotarelo Et al.Mol Brain2015;290:827
- Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier.Authors: Kamekura Et al.Biochem J2015;26:3165
- Docosahexaenoic Acid Induces Cell Death in Human Non-Small Cell Lung Cancer Cells by Repressing mTOR via AMPK Activation and PI3K/Akt Inhibition.Authors: Kim Et al.Biomed Res Int2015;2015:239764
- Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation.Authors: Salmond Et al.J Immunol2015;195:4615
- Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy.Authors: Hsu Et al.Autophagy2015;11:643
- Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells.Authors: Kang Et al.PLoS One2015;10:e0144368
- SILAC-Based Mass Spectrometry Analysis Reveals That Epibrassinolide Induces Apoptosis via Activating Endoplasmic Reticulum Stress in Prostate Cancer Cells.Authors: Obakan Et al.PLoS One2015;10:e0135788
- SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.Authors: Wang Et al.PLoS One2014;8:e83941
- Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1α.Authors: Gonsalves Et al.Am J Hematol2014;89:273
- West nile virus-induced activation of mammalian target of rapamycin complex 1 supports viral growth and viral protein expression.Authors: Shives Et al.J Virol2014;88:9458
- Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation.Authors: Dai Et al.Glia2014;62:2096
- Long-term potentiation can be induced in the CA1 region of hippocampus in the absence of αCaMKII T286-autophosphorylation.Authors: Villers Et al.Learn Mem2014;21:616
- A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.Authors: Mohseni Et al.J Virol2014;16:108
- Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation.Authors: Cope Et al.J Cell Sci2014;127:788
- Parallel measurement of dynamic changes in translation rates in single cells.Authors: Han Et al.Nat Methods2014;11:86
- Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers.Authors: Lefort Et al.Autophagy2014;10:2122
- Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells.Authors: Basu Et al.Autophagy2014;10:1193
- Activation of mammalian target of rapamycin mediates rat pain-related responses induced by BmK I, a sodium channel-specific modulator.Authors: Jiang Et al.Mol Pain2013;9:50
- Herpes simplex virus 2 (HSV-2) prevents dendritic cell maturation, induces apoptosis, and triggers release of proinflammatory cytokines: potential links to HSV-HIV synergy.Authors: Stefanidou Et al.J Biol Chem2013;87:1443
- Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival.Authors: Saxena Et al.Neuron2013;80:80
- Post-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1.Authors: Murthy Et al.Cereb Cortex2013;6:30
- Asymmetrical synaptic cooperation between cortical and thalamic inputs to the amygdale.Authors: FonsecaNeuropsychopharmacology2013;38:2675
- Identification of repurposed small molecule drugs for chordoma therapy.Authors: Xia Et al.Cancer Biol Ther2013;14:638
- Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts.Authors: Gangoiti Et al.Biochimie2012;94:597
- Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens.Authors: Ladoire Et al.Autophagy2012;8:1175
- Fucoidan from seaweed Fucus vesiculosus inhibits migration and invasion of human lung cancer cell via PI3K-Akt-mTOR pathways.Authors: Lee Et al.PLoS One2012;7:e50624
- Ins-like growth factors promote vasculogenesis in embryonic stem cells.Authors: Piecewicz Et al.PLoS One2012;7:e32191
- Passenger deletions generate therapeutic vulnerabilities in cancer.Authors: Muller Et al.Nature2012;488:337
- Erlotinib antagonizes ABC transporters in acute myeloid leukemia.Authors: Lainey Et al.Cell Cycle2012;11:4079
- Pro-autophagic polyphenols reduce the acetylation of cytoplasmic proteins.Authors: Pietrocola Et al.Cell Cycle2012;11:3851
- Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53.Authors: Jing Et al.Sci Rep2011;7:1348
- The angiogenic factor angiopoietin-1 is a proneurogenic peptide on subventricular zone stem/progenitor cells.Authors: Rosa Et al.J Neurosci2010;30:4573
- BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability.Authors: Zhong Et al.J Neurosci2009;29:9977
- Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome.Authors: Muddashetty Et al.J Neurosci2007;27:5338
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rapamycin support human ES cells differentiation
By Pinyuan Tianon 05/22/2019
Application: Species:Human
Rapamycin treatment (10nM) on human embryonic stem cells could enhance some cartilage differentiation markers such as SOX9.
