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Toll-like Receptor 2; CD282; Toll/Interleukin-1 Receptor-like Protein 4; TIL4

Monoclonal Antibody

ABM3A87

Mouse IgG1κ

Recombinant human TLR2 protein (aa 180-420).

APC

Flow Cytometry: (0.5-1μg/106 cells)Optimal conditions must be determined individually for each application.

HumanMouse

Recognizes human and mouse TLR2.

Protein G purified.

0.2mg/ml

Liquid. In PBS containing 0.05% sodium azide.

BLUE ICE

+4°C

+4°C

Do not freeze.Protect from light.

Stable for at least 6 months after receipt when stored at +4°C.

No

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TLR2 (Toll-like Receptor 2) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2 acts via MYD88 and TRAF6, leading to NF-κB activation, cytokine secretion and the inflammatory response. TLR2 resides on the plasma membrane where it responds to lipid-containing pathogen-associated molecular patterns (PAMPs), such as lipoteichoic acid and di- and tri-acylated cysteine-containing lipopeptides. It does this by forming dimeric complexes with either TLR1 or TLR6, which consequently is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infections with these pathogens. TLR2 also interacts with a large number of non-TLR molecules such as LY96 (MD-2), allowing for recognition of a great number and variety of PAMPs (pathogen-associated molecular patterns). TLR2 expression has been detected in immune cells, endothelial and epithelial cells.

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