Human CD137 (4-1BB) is expressed on activated T cells within 24-48 hours of activation (3). CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily (1,2). CD137 appears to be important for T cell proliferation and survival (4) and induces monocyte activation (5).

Molecular Structure: A soluble 55 kd fusion protein consisting of the extracellular (186aa) domain of human CD137 fused to human IgG1 Fc (4), with a predicted monomeric molecular weight of 44.1 kd.

Transfectant Cell Line: CHO

Functional Application: CD137 Ig fusion protein blocks binding of anti-human CD137 to activated CEM human tumor cells and also binds to CD137 Ligand on Raji cells.

References:

1. M.R. Alderson, et al, (1994) Eur J Immunol 24: 2219-2227.

2. H.J. Gruss, and S.K. Dower, (1995) Blood 85: 3378-3404.

3. B.A. Garni-Wagner, et al, (1996) Cellular Immunol 169: 91-98.

4. H. Schwarz, et al, (1996) Blood 87: 2839-2845.

5. J. Langstein, et al, (1998) J Immunol 160: 2488-2494.

Ancell防鼠CD45R（B220）纯化（含抗生素）同种型：  大鼠IgM免疫原：   RAW112细胞信息：抗体RA3-3A1与B220（CD45R）的胞外表位结合，B220是T200的220 kD变异体，存在于B细胞和B细胞前体上。CD45R参与了涉及运动性和枝晶形成的信号传导途径（2）。