Human CD62L is as adhesion molecule found on most leukocytes and plays a primary role in mediating initial leukocyte interaction with activated vascular endothelium (1). Human CD62L has signal transduction functions where engagement leads to increased calcium levels and upregulated expression of certain integrins (2).

Isotype: Murine IgG2a Kappa

Immunogen: Mouse pre-B cells expressing human L-selectin

Specificity: Antibody LAM1-116 recognizes the lectin binding domain of human, mouse, rat and guinea pig CD62L (2, 4). It has also been reported to recognize equine, canine and bovine CD62L.

Functional Application: Antibody LAM1-116 blocks CD62L function and induces expression of beta-1 and beta-2 integrins (1).

References:

1. T.A. Springer, (1995) Annu Rev Physiol 57: 827-872.

2. D.A. Steeber, et al, (1997) J Immunol 159: 952-963.

3. Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 420-424.

4. A.D. Fryer, B.S. Bochner, et al (1997) J Clin Invest 99(8): 2036-2044.

Ancell防鼠CD45R（B220）纯化（含抗生素）同种型：  大鼠IgM免疫原：   RAW112细胞信息：抗体RA3-3A1与B220（CD45R）的胞外表位结合，B220是T200的220 kD变异体，存在于B细胞和B细胞前体上。CD45R参与了涉及运动性和枝晶形成的信号传导途径（2）。