Human CD166 is a type 1 glycoprotein expressed on activated T cells, B cells and monocytes and appears to be the ligand for CD6 (1,2). Human CD166 may be important for activation of T cells.

Isotype: Murine IgG1

Immunogen: Human thymic epithelial cells

Specificity: Antibody 3A6 recognizes the CD166 molecule of 100 kd. It is cross reactive with bovine CD166 (8).

Functional Application: Antibody 3A6 blocks binding of CD6 to CD166. Antibody 3A6 has been used to identify mesenchymal progenitor cells populations (5,6).

References:

1. M.A. Bowen, et al, (1995) J Exp Med 181: 2213-2220.

2. M.A. Bowen, et al, (1996) J Biol Chem 271: 17390-17396.

3. Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 459-465.

4. Spaggiari G.M., L. Moretta, et al. (2006) Blood 107(4): 1484-1490.

5. K Richardson, I.M. Khan, C.W. Archer (2006) Eur Cell & Materials 12 (suppl 1): 70.

6. R Williams, HE McCathy, et al. (2010) PLoS ONE 5(10): e13246 doi:10.1371.

7. O Ozbey, I Ustunel, et al. (2014) Acta Histochem 116(5): 763-70.

8. A Konno, W C Davis, et al. (2001) J Leuk Biol 69: 944-950.

Ancell防鼠CD45R（B220）纯化（含抗生素）同种型：  大鼠IgM免疫原：   RAW112细胞信息：抗体RA3-3A1与B220（CD45R）的胞外表位结合，B220是T200的220 kD变异体，存在于B细胞和B细胞前体上。CD45R参与了涉及运动性和枝晶形成的信号传导途径（2）。