Human CD66b (CEACAM8, CGMb, NCA-95, CD67) is a 95kD member of the Carcinoembryonic Antigen (CEA) group. It is expressed on granulocytes and functions as an adhesion molecule. Similar to the CD66 a, c, and d isoforms, engagement of CD66b on neutrophils causes increased adhesion to endothelial cells (2). Crosslinking CD66b on neutrophils with antibodies triggers IL-8 release (3).

References:

1) W.N. Khan, S. Hammarstrom, et al. (1992) Genomics 14(2):384-90.

2) K.M. Skubitz, A.P. Skubitz, et al. (1996) J Leuk Biol 60(1): 106-117.

3) A.K. Schroder, L Rink, et al. (2006) Human Immunol 67(9): 676-682.

Antibody from clone ANC1D5 binds to CD66b on the cell surface of humanPMN in Flow cytometry and detects recombinant CD66b in sandwich EIAutilizing either clone ANC4A4(Cat #220-020) or ANC3C5(Cat# 219-020) as acapture reagent. Clone ANC1D5 may cross react with other CD66 isoforms, as it also binds to cell surface of an epithelial tumor line.

Ancell防鼠CD45R（B220）纯化（含抗生素）同种型：  大鼠IgM免疫原：   RAW112细胞信息：抗体RA3-3A1与B220（CD45R）的胞外表位结合，B220是T200的220 kD变异体，存在于B细胞和B细胞前体上。CD45R参与了涉及运动性和枝晶形成的信号传导途径（2）。