Human CD70 is not present on resting lymphocytes. CD70 is expressed after activation on about 20% of T cells and on about 70% of B cells. CD70 is a ligand for CD27 and it is also a member of the tumor necrosis factor gene family (3).

Isotype: Murine IgG1

Immunogen: Human WM-1 (Waldenström’s macroglobulinemia) cell line

Specificity: Antibody BU69 recognizes the CD70 molecule of approximately 30 kd (3).

Functional Application: Antibody BU69 blocks the interaction between CD27 and CD70, and has been shown to inhibit T cell proliferation induced by dendritic cells(5).

References:

1. R.Q. Hintzen, et al, (1994) J Immunol 152: 1762-1773.

2. M.R. Bowman, et al, (1994) J Immunol 152: 1756-1761.

3. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1137-1138.

4. K. Agematsu, et al, (1995) J Immunol 154: 3627-3635.

5. S Iwamoto, A Miyazaki, et al, (2005) J Leuk Biol 78: 383-392.

6. Wischhusen J, M Weller, et al. (2002) Cancer Res 62: 2592-2599

7. P.J. Adams, A.L. Harris, et al.(2006) British J Cancer 95:298-306.

8. C Muller, R Kuppers, et al.(2010) Intl Immunol 22(4):289-298.

9. H Yokoi, H Yoshikawa, et al (2003) Lymphology 36: 3674-83. PMID: 12926832

Ancell防鼠CD45R（B220）纯化（含抗生素）同种型：  大鼠IgM免疫原：   RAW112细胞信息：抗体RA3-3A1与B220（CD45R）的胞外表位结合，B220是T200的220 kD变异体，存在于B细胞和B细胞前体上。CD45R参与了涉及运动性和枝晶形成的信号传导途径（2）。