Human DR3 (TRAMP, LARD) was designated TNF receptor superfamily member 25. TL1A is a ligand which can induce apoptosis through a cytoplasmic death domain similar to the CD178-CD95 (FasL-Fas) interaction. Alternatively, engagement of DR3 on T cells can synergize with other activating signals to enhance IFNg production. Clone ANC2D12 binds specifically to recombinant DR3 in EIA, but does not inhibit DR3 binding to TL1A. It does not appear to be suitable for Western blot.

Isotype: Murine IgG1 kappa

Immunogen: Human HPB-MLT cells, recombinant human CD278(ICOS)-muIg

Specificity: Clone ANC2D12 binds specifically to recombinant DR3 in EIA, but does not inhibit DR3 binding to TL1A.

References:

(1) A Kaptein, et al. (2000) FEBS Lett 485:135.

(2) T Migone, et al. (2002) Immunity 16:479. (3) S Targin, et al. (2004) 172: 7002.

Ancell防鼠CD45R（B220）纯化（含抗生素）同种型：  大鼠IgM免疫原：   RAW112细胞信息：抗体RA3-3A1与B220（CD45R）的胞外表位结合，B220是T200的220 kD变异体，存在于B细胞和B细胞前体上。CD45R参与了涉及运动性和枝晶形成的信号传导途径（2）。