Human CD31 is an adhesion molecule expressed on platelets, endothelial cells, leukocytes and their bone marrow precursors. CD31 plays a role in homophilic adhesion and heterophilic transendothelial migration (3).
Isotype: Murine IgG1
Immunogen: Stimulated human leukocytes
Specificity: Antibody 158-2B3 reacts with domain 1 of CD31 (1).
Functional Application: Antibody 158-2B3 blocks homophilic interaction and heterophilic transendothelial migration(1). It has been used for FACS analysis of circulating Endothelial Microparticles (4).
References:
1. Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 362-372.
2. P.J. Newman, (1997) J Clin Invest 99: 3-10.
3. K.L. Yong, et al, (1998) Blood 91: 1196-1205.
4. AF Tramontano, L Ragolia, et al. (2010) Mediators of Inflammation 2010: 250476 doi:10.1155/2010/250476.
5. I Soaita, W Yin, D A Rubenstein (Jan 2017) Platelets http://dx.doi.org/10.1080/09537104.2016.1260703
Ancell防鼠CD45R(B220)纯化(含抗生素)同种型: 大鼠IgM免疫原: RAW112细胞信息:抗体RA3-3A1与B220(CD45R)的胞外表位结合,B220是T200的220 kD变异体,存在于B细胞和B细胞前体上。CD45R参与了涉及运动性和枝晶形成的信号传导途径(2)。