Human tumor necrosis factor alpha (TNF alpha) is a proinflammatory cytokine expressed mainly by activated monocytes and macrophages. TNF alpha exerts a key role with regard to pathogenesis of many infectious and inflammatory diseases.

Isotype: Murine IgG1

Immunogen: Recombinant human TNF alpha

Functional Application: Antibody J1D9 neutralizes TNF alpha biological activities (2). It prevents TNF alpha induced apoptosis in Jurkat cells (5).

References:

1. P. Vassalli, (1992) Annu Rev Immunol 10: 411-452.

2. P.J. McLaughlin, et al, (1992) Anticancer Res 12: 1243-1246.

3. M. Pasparakis, et al, (1996) Cytokine and Growth Factor Reviews 7: 223-229.

4. A. Eigler, et al, (1997) Immunology Today 18: 487-492.

5. Kalli K R, Kaufmann S H, et al. (2003) Molecular Pharmacology 64(6): 1434-1443.

Ancell防鼠CD45R（B220）纯化（含抗生素）同种型：  大鼠IgM免疫原：   RAW112细胞信息：抗体RA3-3A1与B220（CD45R）的胞外表位结合，B220是T200的220 kD变异体，存在于B细胞和B细胞前体上。CD45R参与了涉及运动性和枝晶形成的信号传导途径（2）。