Human DR3 (TRAMP, LARD) was redesignated TNF receptor superfamily member 25. TL1A is a ligand which can induce apoptosis through a cytoplasmic death domain similar to the CD178-CD95 (FasL-Fas) interaction. Alternatively, engagement of DR3 on T cells can synergize with other activating signals to enhance IFN g production.

Recombinant DR3-muIg binds to recombinant TL1A in EIA.

Molecular Structure: A soluble fusion protein combining the extracellular (150aa) domain of human DR3 and murine IgG2a Fc and hinge region (233aa), with a predicted monomeric molecular weight of 42.9 kd.

N-teminal sequence: (27) GTRSP

Transfectant Cell Line:CHO

References:

(1) A Kaptein, et al. (2000) FEBS Lett 485:135.

(2) T Migone, et al. (2002) Immunity 16:479.

(3) S Targin, et al. (2004) 172: 7002.

Ancell防鼠CD45R（B220）纯化（含抗生素）同种型：  大鼠IgM免疫原：   RAW112细胞信息：抗体RA3-3A1与B220（CD45R）的胞外表位结合，B220是T200的220 kD变异体，存在于B细胞和B细胞前体上。CD45R参与了涉及运动性和枝晶形成的信号传导途径（2）。