Antibodies to human CD17 react with lactosylceramide which is expressed on granulocytes, monocytes, platelets, and basophils (1). CD17 expression is downmodulated on activated granulocytes. CD17 is an important componant in CD11b/CD18 mediated phagocytosis of microbes (2).

Isotype: Murine IgM

Immunogen: Human beta-2 microglobulin associated proteins from a detergent lysate of PBL

Specificity: Antibody Huly-m13 requires CD17 on human myeloid cells. It does not recognize mouse LacCer (6).

References:

1. Leukocyte Typing IV (W Knapp, et al, eds.) Oxford University Press, Oxford (1989) p. 877-879.

2. Nakayama H, K Iwabuchi, et al. (2008) J Leukocyte Biol 83:728-741.

3. Rusciani A, Duca L, Sartelet H, Chatron-Colliet A, Bobichon H, et al. (2010)PLoS ONE 5(11): e14010.

4. Chatterjee S, Alsaeedi N, Hou J, Bandaru VVR, Wu L, et al. (2013) PLoS ONE 8(5): e63726.

5. Hulkova H, M Elleder, et al. (2005) Virchows Archiv 447(1): 31-44.

6. K Iwabuchi, K Takamori, et al. (2015) Glycobiology 25(6): 655-68. PMID: 25595946

7. H Nakamura, T Murayama, et al. (2017) J cell Biol 118(12): 4370-4382. PMID:2844490DOI:10.1002/jcb.26091

Ancell防鼠CD45R（B220）纯化（含抗生素）同种型：  大鼠IgM免疫原：   RAW112细胞信息：抗体RA3-3A1与B220（CD45R）的胞外表位结合，B220是T200的220 kD变异体，存在于B细胞和B细胞前体上。CD45R参与了涉及运动性和枝晶形成的信号传导途径（2）。