Molecular Structure: A soluble molecule consisting of murine CD8 alpha signal peptide residual amino acids and linker: (1)kpqapelrgs(10)

A CD70-reactive n-terminal section of the mature extracellular domain of human CD27:

(11)kscperhywaqgklccqmcepgtflvkdcdqhrkaaqcdpcipgvsfspdhhtrphcescrhcnsgllvrnctitanaecacrngwqcrdkectecdplpnps (113)

linker (114)gt(115)

murine IgG2a Fc + hinge regions: (116) eprgptikpcppckcpapnllggpsvfifppkikdvlmislspivtcvvvdvseddpdvqiswfvnnvevhtaqtqthredynstlrvvsalpiqhqdwmsgkefkckvnnkdlpapiertiskpkgsvrapqvyvlpppeeemtkkqvtltcmvtdfmpediyvewtnngktelnykntepvldsdgsyfmysklrvekknwvernsyscsvvheglhnhhttksfsrtpgk (348)

The molecule is dimeric with a predicted monomeric non glycosylated molecular weight of 39.3 kd.

Transfectant Cell Line: CHO

Human CD27 is a lymphocyte specific member of the tumor necrosis factor receptor family (TNFRSF7) and is found primarily on peripheral blood T cells and on a subpopulation of B cells and NK cells. The ligand for CD27 is CD70, which is a member of the TNF ligand superfamily(TNFSF7). The CD27-CD70 interaction plays an important role in T cell activation.

Specificity: Recombinant soluble CD27-muIg binds to cell surface CD70 on Raji cells in FACS, and is reactive with recombinant CD70-muCD8 (cat #537-020), and anti-CD27 mAb clone M-T271 (cat #176-020).

Ancell防鼠CD45R（B220）纯化（含抗生素）同种型：  大鼠IgM免疫原：   RAW112细胞信息：抗体RA3-3A1与B220（CD45R）的胞外表位结合，B220是T200的220 kD变异体，存在于B细胞和B细胞前体上。CD45R参与了涉及运动性和枝晶形成的信号传导途径（2）。