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蚂蚁淘在线 / 品牌中心 / Anaspec / Anaspec/Protease - Activated Receptor - 1, PAR - 1 Agonist, amide/1 mg/AS-62936
商品描述
| Product Name | Protease - Activated Receptor - 1, PAR - 1 Agonist, amideTFLLRNPNDK - NH2 |
| Size | 1 mg |
| Catalog # | AS-62936 |
| US$ | $68 |
| Purity | % Peak Area By HPLC ≥ 95% |
This peptide is a thrombin receptor activating peptide. This PAR-1 agonist peptide reversibly binds to PAR-1 mimicking the "tethered ligand" that thrombin makes available through proteolytic cleavage of substrate.It is also known to cause increase in liquid and protein permeability much like thrombin. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Vogel, SM. et al. Physiol. Genom. 4:137-145 (2000). |
| Molecular Weight | 1216.4 |
| TFLLRNPNDK-NH2 | |
| Sequence(Three-Letter Code) | H - Thr - Phe - Leu - Leu - Arg - Asn - Pro - Asn - Asp - Lys - NH2 |
| Product Citations | Kouzaki, H. et al. (2013). Transcription of Interleukin-25 and extracellular release of the protein is regulated by allergen proteases in airway epithelial cells J. Resp. Cell. Mol. Biol49(5):741-750. doi:10.1165/rcmb.2012-0304OCMosnier, L. O. (2012). Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46 Blood doi: http://dx.doi.org/10.1182/blood-2012-08-452169. Wang, W. et al. (2009). Kallikrein-related peptidase-4 initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1. Int J Cancer126, 599. doi: 10.1002/ijc.24904. |
