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商品描述
| Product Name | Bid BH3 - r8rrrrrrrr - GEDIIRNIARHLAQVGDSMDR |
| Size | 0.5 mg |
| Catalog # | AS-61715 |
| US$ | $374 |
| Purity | % Peak Area By HPLC ≥ 95% |
The Bid BH3 is a pro-apoptotic member of the "BH3-only" subset of BCL-2 family proteins that constitute a critical control point in apoptosis. r8BIDBH3 is lethal to human leukemia cell lines that expresse Bcl-2. The Bcl-2 antagonists may have the potential to be efficacious in cancer therapy. Poly-D-arginine (d-isomer as denoted by rrrrrrrr) is fused to the Bid BH3 peptide to facilitate cellular uptake of the peptide. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Letai, A. J.Clin. Invest. 115, 2648 (2005); Mendoza, F. et al. Arch. Immunol. Ther. Exp. 53, 47 (2002). |
| Molecular Weight | 3616.2 |
| rrrrrrrr-GEDIIRNIARHLAQVGDSMDR | |
| Sequence(Three-Letter Code) | H - D - Arg - D - Arg - D - Arg - D - Arg - D - Arg - D - Arg - D - Arg - D - Arg - Gly - Glu - Asp - Ile - Ile - Arg - Asn - Ile - Ala - Arg - His - Leu - Ala - Gln - Val - Gly - Asp - Ser - Met - Asp - Arg |
