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商品描述
| Product Name | Endothelin 1, human, porcineCSCSSLMDKECVYFCHLDIIW (Disulfide bridge: 1 - 15 and 3 - 11) |
| Size | 0.5 mg |
| Catalog # | AS-22860 |
| US$ | $300 |
| Purity | % Peak Area By HPLC ≥ 95% |
ET-1 is a potent vasoconstrictor peptide derived from endothelial cells. It plays a role in regulation of cardiovascular functions. The binding of ET-1 to G-protein coupled receptor triggers a signal transduction cascade leading to activation of the protein kinase C (PKC). PKC inhibitor potentially reverses the up regulation of ET-1. The enhanced ET-1 expression associated with the activation of PKC occurs in early diabetes. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Ref: Yanagisawa, M. et al. Nature. 332, 411 (1988). |
| Molecular Weight | 2492 |
| CSCSSLMDKECVYFCHLDIIW (Disulfide bridge: 1-15 and 3-11) | |
| Sequence(Three-Letter Code) | H - Cys - Ser - Cys - Ser - Ser - Leu - Met - Asp - Lys - Glu - Cys - Val - Tyr - Phe - Cys - His - Leu - Asp - Ile - Ile - Trp - OH (Disulfide bridge: 1 - 15 and 3 - 11) |
| Product Citations | Ansar, S. et al. (2009). Equal contribution of increased intracranial pressure and subarachnoid blood to cerebral blood flow reduction and receptor upregulation after subarachnoid hemorrhage. J Neurosurg 111, 5.Wang, Y. et al. Brain Res. 1167, 118 (2007).Cervar-Zivkovic, M. et al. Reprod. Sci. 14, 430 (2007).Beg, SAS. et al. J. Cer. Blood Flow Metab. 26, 846 (2006).Ansar, S. et al. J. Neurosurgery 106, DOI: 10.3171/jns.2007.106.5.881 (2006). |
