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商品描述
| Product Name | Cls Substrate, C2 (Abz/Dnp)2Abz - SLGRKIQIK(Dnp) - NH2 |
| Size | 1 mg |
| Catalog # | AS-61315 |
| US$ | $191 |
| Purity | % Peak Area By HPLC ≥ 95% |
This peptide is a second complement component (C2), the physiological substrate for the proenzyme Cls, first complement component. The complement system is a central component of host defense but can also contribute to the inflammation seen in pathological conditions. The C1s protease of the C1 complex initiates the host defense pathway. This peptide employs 2Abz/Dnp FRET pair for quantitation of complement enzyme activity. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Kerr, F. et al. J. Biol. Chem. 280, 39510 (2005), S. Nagasawa, and R. Stroud PNAS 74, 2998 (1977). |
| Molecular Weight | 1326.5 |
| 2Abz-SLGRKIQIK(Dnp)-NH2 | |
| Sequence(Three-Letter Code) | 2Abz - Ser - Leu - Gly - Arg - Lys - Ile - Gln - Ile - Lys(Dnp) - NH2 |
| Product Citations | Brannon, R. J. et al. (2015). Antimicrobial peptide conformation as a structural determinant of omptin protease specificity JB 197 doi: 10.1128/JB.00469-15 Thomassin, JL. et al. (2012). OmpT outer membrane proteases of enterohemorrhagic and enteropathogenic Escherichia coli contribute differently to the degradation ofhuman LL-37Infect Immun 80, 483. doi: 10.1128/IAI.05674-11 . |
