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商品描述
| Product Name | TAT - NSF700 Fusion PeptideYGRKKRRQRRR - GGG - LLDYVPIGPRFSNLVLQALLVL |
| Size | 1 mg |
| Catalog # | AS-62238 |
| US$ | $335 |
This peptide is the N-Ethyl-maleimide-sensitive factor (NSF) inhibitor fusion polypeptide composed of 11-amino acid cell permeable HIV transactivating regulatory protein (TAT) domain fused to a 22 amino acid NSF domain. TAT-NSF700 inhibits thrombin-induced exocytosis of endothelial cells in a dose-responsive manner. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Matsushita, K. et al. Mol. Pharmacol. 67,1137 (2005). |
| Molecular Weight | 4167 |
| YGRKKRRQRRR-GGG-LLDYVPIGPRFSNLVLQALLVL | |
| Sequence(Three-Letter Code) | H - Tyr - Gly - Arg - Lys - Lys - Arg - Arg - Gln - Arg - Arg - Arg - Gly - Gly - Gly - Leu - Leu - Asp - Tyr - Val - Pro - Ile - Gly - Pro - Arg - Phe - Ser - Asn - Leu - Val - Leu - Gln - Ala - Leu - Leu - Val - Leu - OH |
| Product Citations | Morrell, C. N. et al. (2005). A Novel Inhibitor of N-Ethylmaleimide-Sensitive Factor Decreases Leukocyte Trafficking and Peritonitis J Pharmacol Exp Ther 314 155. doi: 10.1124/jpet.104.082529. Trang, T. et al. (2009). P2X4-Receptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation. J Neurosci 29, 3518.Matsushita, K. et al. (2005). A Novel Class of Fusion Polypeptides Inhibits Exocytosis. Mol Pharmacol 67, 1137. |
