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蚂蚁淘在线 / 品牌中心 / Anaspec / Anaspec/Protease - Activated Receptor - 3, PAR - 3 Agonist, amide/1 mg/AS-62938
商品描述
| Product Name | Protease - Activated Receptor - 3, PAR - 3 Agonist, amideSFNGGP - NH2 |
| Size | 1 mg |
| Catalog # | AS-62938 |
| US$ | $68 |
| Purity | % Peak Area By HPLC ≥ 95% |
This peptide is one of the four PAR sub-types, and is acted upon by thrombin; not trypsin. It is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. PARs have been studied for their roles in itch and, their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR4. Co-expression of PAR3 and PAR4enhances thrombin action suggesting that PAR3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR4. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | 1, Tsujii, K. et al. J Pharmacol Sci. 108:385-388 (2008). 2, Leger, AJ. et al. Circ, 114:1070-1077 (2006). |
| Molecular Weight | 576.6 |
| SFNGGP-NH2 | |
| Sequence(Three-Letter Code) | H - Ser - Phe - Asn - Gly - Gly - Pro - NH2 |
| Product Citations | Keiichi, I. et al. (2014). Protease activated receptor-1, but not -2, -3 and -4, is the player in the pathogenesis of atrial fibrosis; the experiment by neonatal rat atrial fibroblasts. IJC Heart & Vess 2:21-23. doi: 10.1016/j.ijchv.2013.11.005 Firth, AL. et al. (2009). Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells. Am. J. Physiol. Heart. Circ. Physiol 296, L979. doi: 10.1152/ajplung.90412.2008.Rauch, BH. et al. (2004). Thrombin- and Factor Xainduced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells. Circ. Res 94, 340. doi: 10.1161/01.RES.0000111805.09592.D8 |
