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Anaspec/SensoLyte ® Transglutaminase Activity Assay Kit, Colorimetric/1 kit/AS-72244

价格
¥9600.00
货号:AS-72244
浏览量:100
品牌:Anaspec
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商品描述
Description
Product NameSensoLyte ® Transglutaminase Activity Assay Kit, Colorimetric
Size1 kit
Catalog #AS-72244
US$$480

Transglutaminases (TGs) are Ca2+and thiol-dependent enzymes that catalyze posttranslational modifications ofproteins. These covalent reactions include formation of isopeptide linkagesbetween the carboxamide groups of protein-bound glutamine residues and ε-aminogroups of protein-bound lysine and polyamine residues, hydrolysis andesterification of glutamine residues. Family of TGs includes at least nine members: TG 1-7, coagulation factor XIIIa,and the keratinocyte membrane bound TG form. TG has attracted considerable interest as apotential drug target. Its activity isthought to contribute to Alzheimer disease, Parkinson disease, Huntingtondisease, and supranuclear palsy.

SensoLyte®Transglutaminase Activity Assay Kit provides a convenient assay for the highthroughput screening of TG modulators and inhibitors. TG catalyzes covalentbond formation between a free amine group of poly-D-lysine, which is coated onthe plate surface, and γ-carboxamide group of glutamine in biotin-TVQQELpeptide substrate. The reaction immobilizes biotin-conjugated peptide to theplate surface. The amount of immobilized biotin is determined usingstreptavidin-horseradishperoxidase (HRP) andTMB substrate. Colorimetric signal generated by HRP and TMBsubstrate is proportional to the activity of TG in a sample. Assay is performedin a convenient 96-well microplate format.

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AnaSpec是一家由多肽合成、荧光标记、抗体、树脂合成专家团队组成的生物企业,为全世界的科研工作者提供全套的蛋白质组学研究解决方案。产品线主要分三个部分:多肽、检测试剂和树脂等化学试剂,适合基础研究、高通量筛选和药物发现等方面;还提供多肽合成、抗体生产和分析试剂盒开发。能合成不同数量级(mg-g级)的多种长度序列肽,常规合成肽为50个氨基酸或更长。2009年,美国Anaspec公司被Eurogentec收购