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Anaspec/Human PD - L1 inhibitor V/1 mg/AS-65585

价格
¥2260.00
货号:AS-65585
浏览量:102
品牌:Anaspec
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商品描述
DescriptionSequence(One-Letter Code)
Product NameHuman PD - L1 inhibitor V
Size1 mg
Catalog #AS-65585
US$$113
PurityPeak Area by HPLC ≥95%

Programed cell death protein 1 (PD-1) is a cell surface receptor. PD-1 and its ligand PD-L1 are crucial immune checkpoints to downregulate T cell activation, tolerance and immunopathology. Several types of cancer cells overexpress PD-L1 in order to escape from the PD-1/PD-L1 immunosurveillance mechanism. Human PD-L1 inhibitor V is a peptide-based molecule. It binds to human PD-1 and inhibits PD-1/PD-L1 binding.This peptide, hPDL-1 inhibitor V has anchor residues (underlined), LDYVNRRKMYQ that influence binding of hPD-L1 to hPD-1. Developing inhibitors specifically blocking the PD-1/PD-L1 pathway has become a popular approach toward cancer treatment.PD-L1 Related Peptides:Human PD-L1 inhibitor I, Cat# AS-65581Human PD-L1 inhibitor II, Cat# AS-65582Human PD-L1 inhibitor III, Cat# AS-65583Human PD-L1 inhibitor IV, Cat# AS-65584

Detailed InformationDatasheet
Material Safety Data Sheets (MSDS)
ReferencesBardhan K., et.al, Front Immunol 7(550), (2016); Li Q., et.al, Oncotarget 7(40), 64967-64976 (2016); D"Errico G., et.al, Clin Transl Med 6(1), 3-12 (2017)
Molecular Weight1485.8
LDYVNRRKMYQ
Sequence(Three-Letter Code)H - Leu - Asp - Tyr - Val - Asn - Arg - Arg - Lys - Met - Tyr - Gln - OH
AnaSpec是一家由多肽合成、荧光标记、抗体、树脂合成专家团队组成的生物企业,为全世界的科研工作者提供全套的蛋白质组学研究解决方案。产品线主要分三个部分:多肽、检测试剂和树脂等化学试剂,适合基础研究、高通量筛选和药物发现等方面;还提供多肽合成、抗体生产和分析试剂盒开发。能合成不同数量级(mg-g级)的多种长度序列肽,常规合成肽为50个氨基酸或更长。2009年,美国Anaspec公司被Eurogentec收购