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蚂蚁淘在线 / 品牌中心 / Anaspec / Anaspec/Protease - Activated Receptor - 4, PAR - 4 Agonist, amide/5 mg/AS-60218-5
商品描述
| Product Name | Protease - Activated Receptor - 4, PAR - 4 Agonist, amideAYPGKF - NH2 |
| Size | 5 mg |
| Catalog # | AS-60218-5 |
| US$ | $272 |
| Purity | % Peak Area By HPLC ≥ 95% |
PAR-4 agonist peptide stimulates thromboxane production by human platelets with the maximal response to this agonist being approximately half of that observed after maximal thrombin stimulation. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Ref: Sabri, A. et al. J. Biol. Chem. 278, 11714 (2003); Ma, L. et al. Proc. Natl. Acad. Sci. USA 102, 216 (2005). |
| Molecular Weight | 680.8 |
| AYPGKF-NH2 | |
| Sequence(Three-Letter Code) | H - Ala - Tyr - Pro - Gly - Lys - Phe - NH2 |
| Product Citations | Naik, M.U. et al. (2009). CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin αIIbβ3 J Thrombosis Haemostasis 7 doi: 10.1111/j.1538-7836.2009.03581.x.Lindsey, S. et al. (2014). Platelets from mice lacking the aryl hydrocarbon receptor exhibit defective collagen-dependent signaling J Thrombosis Haemostasis 12 doi: 10.1111/jth.12490. Naik, M. U. et al. (2012). JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets blood119 doi: 10.1182/blood-2011-12-397398. Patil, S.B. et al. (2010). Ticagrelor effectively and reversibly blocks murine platelet P2Y12-mediated thrombosis and demonstrates a requirement for sustained P2Y12 inhibition to prevent subsequent neointima Am Heart Assoc doi: 10.1161/ATVBAHA.110.210732.Panicot-Dubois, L. et al. (2007). Bile saltdependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans J Clinical Invest doi:10.1172/JCI32655. Erhard, J.A. et al. (2006). P2X1 stimulation promotes thrombin receptor-mediated platelet aggregation J Thrombosis Haemostasis4 doi: 10.1111/j.1538-7836.2006.01849.x. Rauch, B. H. et al. (2003) Thrombin- and factor XaInduced DNA synthesis Is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells Am Heart Assoc doi: 10.1161/01.RES.0000111805.09592.D8. Murad, JP. et al. (2012). Characterization of the in vivo antiplatelet activity of the antihypertensive agent losartan J Cardiovasc Pharmacol Ther 17 308. doi: 10.1177/1074248411425491.Su, X. et al.(2005) Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms 1J Immunol 175 doi: 10.4049/jimmunol.175.4.2598.Kataoka, H. et al. (2003). Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells Blood 102 doi: 10.1182/blood-2003-04-1130. |
