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蚂蚁淘在线 / 品牌中心 / Anaspec / Anaspec/Endothelin 1, human, HiLyteᵀᴹ Fluor 488 - labeled/0.25 mg/AS-64817-025
商品描述
| Product Name | Endothelin 1, human, HiLyteᵀᴹFluor 488 - labeledHiLyte Fluor 488 - CSCSSLMDKECVYFCHLDIIW(Disulfide Bridge: 1 - 15 and 3 - 11) |
| Size | 0.25 mg |
| Catalog # | AS-64817-025 |
| US$ | $421 |
| Purity | % Peak Area By HPLC ≥ 95% |
This is a fluorescent (HiLyte Fluor 488)-labeled Endothelin 1 (ET-1) peptide, Abs/Em=503/528 nm. ET-1 is a potent vasoconstrictor peptide derived from endothelial cells. It plays a role in regulation of cardiovascular functions. The binding of ET-1 to G-protein coupled receptor triggers a signal transduction cascade leading to activation of the protein kinase C (PKC). PKC inhibitor potentially reverses the up regulation of ET-1. The enhanced ET-1 expression associated with the activation of PKC occurs in early diabetes. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Yanagisawa, M. et al. Nature 332, 411 (1988). |
| Molecular Weight | 2848.4 |
| HiLyte Fluor 488-CSCSSLMDKECVYFCHLDIIW(Disulfide Bridge: 1-15 and 3-11) | |
| Sequence(Three-Letter Code) | Hilyte Fluor 488 - Cys - Ser - Cys - Ser - Ser - Leu - Met - Asp - Lys - Glu - Cys - Val - Tyr - Phe - Cys - His - Leu - Asp - Ile - Ile - Trp - OH(Disulfide Bridge: 1 - 15 and 3 - 11) |
| Product Citations | Gärtner F, et al. 2013. Desensitization and internalization of endothelin receptor A: impact of G protein-coupled receptor kinase 2 (GRK2)-mediated phosphorylation. J Biol Chem. 2013 ;288(45):32138-48. doi: 10.1074/jbc.M113.461566. |
