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商品描述
| Product Name | Bid BH3 PeptideEDIIRNIARHLAQVGDSMDR |
| Size | 1 mg |
| Catalog # | AS-61711 |
| US$ | $125 |
| Purity | % Peak Area By HPLC ≥ 95% |
BID is a pro-apoptotic member of the "BH3-only" (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Oh, K. J. et al J. Biol. Chem. 280, 753 (2005); Oh, K. J. et al. J. Biol. Chem. 281, 36999 (2006); Manero, F. et al. Cancer Res. 66, 2757 (2006); Zhai, D. et al. J. Biol. Chem. 280, 15815 (2005); Walensky, L. et al. Mol. Cell. 24, 199 (2006); Onuki, R. et al. Proc. Natl. Acad. Sci. U S A 99, 14716 (2002);Wang, K. Gen. Develop. 10, 2859 (1996). |
| Molecular Weight | 2309.6 |
| EDIIRNIARHLAQVGDSMDR | |
| Sequence(Three-Letter Code) | H - Glu - Asp - Ile - Ile - Arg - Asn - Ile - Ala - Arg - His - Leu - Ala - Gln - Val - Gly - Asp - Ser - Met - Asp - Arg - OH |
| Product Citations | Chipuk, J. et al. (2008). Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. PNAS 105,20327.Vaugh, AE. et al. (2008). Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c. Nature Cell Biol. 10, 1477. |
