Chaperonin GroE is a 21mer protein complex composed of the subunitsGroEL (14mer, 57 kDa) and GroES (7mer, 10 kDa).This complexis thought tosupport protein expression and folding ability, enablingproteinsto form tertiary structures upon (or immediately after) translation. Chaperonin GroE is essential to the assembly (and presumably reassembly after denaturation) of protein complexes in vivo. Both chaperonin GroEL and GroEScan be used for refolding denatured proteins to recover functional activity.