The Magnosphere UltraPure mRNA Purification Kit is designed for mRNA purification from total RNA derived from cultured cells or animal tissues. This mRNA isolation kit includes Magnosphere oligo-dT beads (JSR Life Sciences Corporation) that are capable of isolating intact, high-purity, polyA+ RNA with an extremely low rate of ribosomal RNA (rRNA) contamination. The beads have a uniform particle size and super paramagnetism, allowing efficient isolation on a magnetic plate without the need for centrifugation. Compared with conventional magnetic particles, this product has lower nonspecific adsorption of impurities on the particle surface, allowing specific and efficient recovery of polyA+ RNA from even trace amounts of total RNA.