Xfect RNA Transfection Reagent is a complete system for highly efficient transfection of mammalian cells with all types of RNA, including messenger RNA, siRNA, single guide RNA (sgRNA), and microRNA. The protocol is simple, requires no optimization, and transfections can be carried out entirely in the presence of serum. While most transfection reagents can be harmful to your cells, the Xfect RNA Transfection Reagent has very low cytotoxicity.